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Sleep quality, BDNF genotype and gene expression in individuals with chronic abdominal pain
BACKGROUND: Sleep quality and genetics may contribute to the etiology of gastrointestinal (GI) symptoms. Individuals with impaired sleep often have a number of associated symptoms including chronic abdominal pain (CAP). The current study examined the interactions of brain-derived neurotrophic factor...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4226913/ https://www.ncbi.nlm.nih.gov/pubmed/25358868 http://dx.doi.org/10.1186/s12920-014-0061-1 |
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author | Reddy, Swarnalatha Y Rasmussen, Nat A Fourie, Nicolaas H Berger, Rebecca S Martino, Angela C Gill, Jessica Longchamps, Ryan Wang, Xiao Min Heitkemper, Margaret M Henderson, Wendy A |
author_facet | Reddy, Swarnalatha Y Rasmussen, Nat A Fourie, Nicolaas H Berger, Rebecca S Martino, Angela C Gill, Jessica Longchamps, Ryan Wang, Xiao Min Heitkemper, Margaret M Henderson, Wendy A |
author_sort | Reddy, Swarnalatha Y |
collection | PubMed |
description | BACKGROUND: Sleep quality and genetics may contribute to the etiology of gastrointestinal (GI) symptoms. Individuals with impaired sleep often have a number of associated symptoms including chronic abdominal pain (CAP). The current study examined the interactions of brain-derived neurotrophic factor (BDNF) genotype with sleep quality in persons with CAP and healthy controls. In addition, associations among sleep quality, BDNF genotype, and gene expression were explored in the participants. METHODS: Data were collected on 59 participants (46% male, 61% White, 26.9 ± 6.6 years; CAP (n=19) and healthy controls (n=40)). Participants with CAP reported poorer sleep quality compared to healthy controls. BDNF genotype, categorized as Val/Val homozygotes versus the Met carriers. RESULTS: Microarray analysis found twenty-four differentially expressed genes by a two-fold magnitude in participants with poor sleep quality compared to good sleep quality, and seven differentially expressed genes comparing CAP to healthy control. Three specific genes in the pain group overlap with sleep quality, including insulin-like growth factor 1 (IGF1), spermatogenesis associated serine-rich 2-like (SPATS2L), and immunoglobulin heavy constant gamma 1 or mu (IGHG1/// IGHM). BDNF was shown to have an interaction effect with GI and sleep symptoms. CONCLUSIONS: Participants with CAP reported poor sleep quality compared to healthy controls. The role of the BDNF Met allele on differential gene expression was not distinct as main factor, but impacted interactions with sleep quality and CAP. Down-regulation of IGF1, SPATS2L, and IGHG1 expression may be related to the etiology of poor sleep quality and CAP. TRIAL REGISTRATION: Clinicaltrial.gov # NCT00824941 ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12920-014-0061-1) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-4226913 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-42269132014-11-12 Sleep quality, BDNF genotype and gene expression in individuals with chronic abdominal pain Reddy, Swarnalatha Y Rasmussen, Nat A Fourie, Nicolaas H Berger, Rebecca S Martino, Angela C Gill, Jessica Longchamps, Ryan Wang, Xiao Min Heitkemper, Margaret M Henderson, Wendy A BMC Med Genomics Research Article BACKGROUND: Sleep quality and genetics may contribute to the etiology of gastrointestinal (GI) symptoms. Individuals with impaired sleep often have a number of associated symptoms including chronic abdominal pain (CAP). The current study examined the interactions of brain-derived neurotrophic factor (BDNF) genotype with sleep quality in persons with CAP and healthy controls. In addition, associations among sleep quality, BDNF genotype, and gene expression were explored in the participants. METHODS: Data were collected on 59 participants (46% male, 61% White, 26.9 ± 6.6 years; CAP (n=19) and healthy controls (n=40)). Participants with CAP reported poorer sleep quality compared to healthy controls. BDNF genotype, categorized as Val/Val homozygotes versus the Met carriers. RESULTS: Microarray analysis found twenty-four differentially expressed genes by a two-fold magnitude in participants with poor sleep quality compared to good sleep quality, and seven differentially expressed genes comparing CAP to healthy control. Three specific genes in the pain group overlap with sleep quality, including insulin-like growth factor 1 (IGF1), spermatogenesis associated serine-rich 2-like (SPATS2L), and immunoglobulin heavy constant gamma 1 or mu (IGHG1/// IGHM). BDNF was shown to have an interaction effect with GI and sleep symptoms. CONCLUSIONS: Participants with CAP reported poor sleep quality compared to healthy controls. The role of the BDNF Met allele on differential gene expression was not distinct as main factor, but impacted interactions with sleep quality and CAP. Down-regulation of IGF1, SPATS2L, and IGHG1 expression may be related to the etiology of poor sleep quality and CAP. TRIAL REGISTRATION: Clinicaltrial.gov # NCT00824941 ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12920-014-0061-1) contains supplementary material, which is available to authorized users. BioMed Central 2014-10-31 /pmc/articles/PMC4226913/ /pubmed/25358868 http://dx.doi.org/10.1186/s12920-014-0061-1 Text en © Reddy et al.; licensee BioMed Central Ltd. 2014 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Reddy, Swarnalatha Y Rasmussen, Nat A Fourie, Nicolaas H Berger, Rebecca S Martino, Angela C Gill, Jessica Longchamps, Ryan Wang, Xiao Min Heitkemper, Margaret M Henderson, Wendy A Sleep quality, BDNF genotype and gene expression in individuals with chronic abdominal pain |
title | Sleep quality, BDNF genotype and gene expression in individuals with chronic abdominal pain |
title_full | Sleep quality, BDNF genotype and gene expression in individuals with chronic abdominal pain |
title_fullStr | Sleep quality, BDNF genotype and gene expression in individuals with chronic abdominal pain |
title_full_unstemmed | Sleep quality, BDNF genotype and gene expression in individuals with chronic abdominal pain |
title_short | Sleep quality, BDNF genotype and gene expression in individuals with chronic abdominal pain |
title_sort | sleep quality, bdnf genotype and gene expression in individuals with chronic abdominal pain |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4226913/ https://www.ncbi.nlm.nih.gov/pubmed/25358868 http://dx.doi.org/10.1186/s12920-014-0061-1 |
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