Three cases of corticosteroid therapy triggering ventricular fibrillation in J-wave syndromes

We describe three cases of J-wave syndrome in which ventricular fibrillation (VF) was probably induced by corticosteroid therapy. The patients involved were being treated with prednisolone for concomitant bronchial asthma. One of the three patients had only one episode of VF during her long follow-u...

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Detalles Bibliográficos
Autores principales: Sakamoto, Naka, Sato, Nobuyuki, Goto, Masahide, Kobayashi, Motoi, Takehara, Naofumi, Takeuchi, Toshiharu, Talib, Ahmed Karim, Sugiyama, Eitaro, Minoshima, Akiho, Tanabe, Yasuko, Akasaka, Kazumi, Kawabe, Junichi, Kawamura, Yuichiro, Doi, Atsushi, Hasebe, Naoyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Japan 2013
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4226925/
https://www.ncbi.nlm.nih.gov/pubmed/24281399
http://dx.doi.org/10.1007/s00380-013-0443-x
Descripción
Sumario:We describe three cases of J-wave syndrome in which ventricular fibrillation (VF) was probably induced by corticosteroid therapy. The patients involved were being treated with prednisolone for concomitant bronchial asthma. One of the three patients had only one episode of VF during her long follow-up period (14 years). Two patients had hypokalemia during their VF episodes. Corticosteroids have been shown to induce various types of arrhythmia and to modify cardiac potassium channels. We discuss the possible association between corticosteroid therapy and VF in J-wave syndrome based on the cases we have encountered.

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