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Type II collagen antibody response is enriched in the synovial fluid of rheumatoid joints and directed to the same major epitopes as in collagen induced arthritis in primates and mice

INTRODUCTION: Antibodies towards type II collagen (CII) are detected in patients with rheumatoid arthritis (RA) and in non-human primates and rodents with collagen induced arthritis (CIA). We have previously shown that antibodies specific for several CII-epitopes are pathogenic using monoclonal anti...

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Detalles Bibliográficos
Autores principales: Lindh, Ingrid, Snir, Omri, Lönnblom, Erik, Uysal, Hüseyin, Andersson, Ida, Nandakumar, Kutty Selva, Vierboom, Michel, 't Hart, Bert, Malmström, Vivianne, Holmdahl, Rikard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4226996/
https://www.ncbi.nlm.nih.gov/pubmed/25005029
http://dx.doi.org/10.1186/ar4605