A single point mutation in cyclin T1 eliminates binding to Hexim1, Cdk9 and RNA but not to AFF4 and enforces repression of HIV transcription

BACKGROUND: Human immunodeficiency virus (HIV) gene expression is primarily regulated at the step of transcription elongation. The viral Tat protein recruits the Positive Transcription Elongation Factor b (P-TEFb) and the Super Elongation Complex (SEC) to the HIV promoter and enhances transcription...

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Detalles Bibliográficos
Autores principales: Kuzmina, Alona, Verstraete, Nina, Galker, Sigal, Maatook, Maayan, Bensaude, Olivier, Taube, Ran
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4226998/
https://www.ncbi.nlm.nih.gov/pubmed/24985467
http://dx.doi.org/10.1186/1742-4690-11-51

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