Relationship of PIK3CA mutation and pathway activity with antiproliferative response to aromatase inhibition

INTRODUCTION: PIK3CA (phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit α) somatic mutations are the most common genetic alteration in breast cancer (BC). Their prognostic value and that of the phosphatidylinositol 3-kinase (PI3K) pathway in BC remains only partly defined. The effect...

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Detalles Bibliográficos
Autores principales: López-Knowles, Elena, Segal, Corrinne V, Gao, Qiong, Garcia-Murillas, Isaac, Turner, Nicholas C, Smith, Ian, Martin, Lesley-Ann, Dowsett, Mitch
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4227109/
https://www.ncbi.nlm.nih.gov/pubmed/24981670
http://dx.doi.org/10.1186/bcr3683

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