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Quality of life in individuals living with HIV/AIDS attending a public sector antiretroviral service in Cape Town, South Africa
BACKGROUND: Health related quality of life (HRQoL) is an important outcome helping to understand the impact of antiretroviral therapy (ART). We examined and compared the HRQoL in relation to ART status among HIV-infected patients in a public sector service in Cape Town, South Africa. In addition, we...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4227123/ https://www.ncbi.nlm.nih.gov/pubmed/24990360 http://dx.doi.org/10.1186/1471-2458-14-676 |
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author | Nglazi, Mweete D West, Sacha J Dave, Joel A Levitt, Naomi S Lambert, Estelle V |
author_facet | Nglazi, Mweete D West, Sacha J Dave, Joel A Levitt, Naomi S Lambert, Estelle V |
author_sort | Nglazi, Mweete D |
collection | PubMed |
description | BACKGROUND: Health related quality of life (HRQoL) is an important outcome helping to understand the impact of antiretroviral therapy (ART). We examined and compared the HRQoL in relation to ART status among HIV-infected patients in a public sector service in Cape Town, South Africa. In addition, we aimed to examine the relationship between ART status and HRQoL according to CD4 count strata. METHODS: A cross sectional study sample of 903 HIV-infected patients who were categorized as not receiving ART (ART-naïve) or receiving first-line ART for > 6 months (ART). HRQoL outcomes were compared in the two groups. HRQoL was assessed using the EQ-5D (five domains) and Visual Analogue Scale (EQ-5D VAS). RESULTS: Of the total sample, 435 were categorised as ART naïve (76% women) and 468 were on ART (78% women). There were no significant associations between groups for most of the EQ-5D domains, however ART-naïve experienced a significantly greater problem with mobility than the ART group. Being ART-naïve (adjusted odds ratio (aOR) 3.08 95% confidence interval (CI) 1.63- 7.89) and obese 2.78 (95% CI 1.24- 6.22) were identified as predictors for increased mobility problems in multivariate analysis. In addition, receiving ART (5.61 difference; 95% CI 2.50 - 8.72) and having some source of income (4.76; 95% CI 1.63 -7.89) were identified as predictors for a higher EQ-5D VAS score. When grouped according to CD4 count strata, there were no significant difference between groups for most of the EQ-5D domains, however the ART-naïve group indicated having significantly greater problems under the CD4 count of >500 cells/μL in the anxiety/depression domain (22.4% vs 8.8%, p = 0.018) and significantly lower EQ-5D VAS scores under the CD4 counts of ≤200 cells/μL (median 80 (IQR 60–90) vs 90 (IQR 80–100), p = 0.0003) and 201–350 cells/μL (median 80 (IQR 70–90) vs 90 (80–100), p = 0.0004) compared to ART group. CONCLUSIONS: HRQoL (self-rated health state) was improved with ART use, including those with immunocompromised status, which may be relevant to the public sector ART program in South Africa. |
format | Online Article Text |
id | pubmed-4227123 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-42271232014-11-12 Quality of life in individuals living with HIV/AIDS attending a public sector antiretroviral service in Cape Town, South Africa Nglazi, Mweete D West, Sacha J Dave, Joel A Levitt, Naomi S Lambert, Estelle V BMC Public Health Research Article BACKGROUND: Health related quality of life (HRQoL) is an important outcome helping to understand the impact of antiretroviral therapy (ART). We examined and compared the HRQoL in relation to ART status among HIV-infected patients in a public sector service in Cape Town, South Africa. In addition, we aimed to examine the relationship between ART status and HRQoL according to CD4 count strata. METHODS: A cross sectional study sample of 903 HIV-infected patients who were categorized as not receiving ART (ART-naïve) or receiving first-line ART for > 6 months (ART). HRQoL outcomes were compared in the two groups. HRQoL was assessed using the EQ-5D (five domains) and Visual Analogue Scale (EQ-5D VAS). RESULTS: Of the total sample, 435 were categorised as ART naïve (76% women) and 468 were on ART (78% women). There were no significant associations between groups for most of the EQ-5D domains, however ART-naïve experienced a significantly greater problem with mobility than the ART group. Being ART-naïve (adjusted odds ratio (aOR) 3.08 95% confidence interval (CI) 1.63- 7.89) and obese 2.78 (95% CI 1.24- 6.22) were identified as predictors for increased mobility problems in multivariate analysis. In addition, receiving ART (5.61 difference; 95% CI 2.50 - 8.72) and having some source of income (4.76; 95% CI 1.63 -7.89) were identified as predictors for a higher EQ-5D VAS score. When grouped according to CD4 count strata, there were no significant difference between groups for most of the EQ-5D domains, however the ART-naïve group indicated having significantly greater problems under the CD4 count of >500 cells/μL in the anxiety/depression domain (22.4% vs 8.8%, p = 0.018) and significantly lower EQ-5D VAS scores under the CD4 counts of ≤200 cells/μL (median 80 (IQR 60–90) vs 90 (IQR 80–100), p = 0.0003) and 201–350 cells/μL (median 80 (IQR 70–90) vs 90 (80–100), p = 0.0004) compared to ART group. CONCLUSIONS: HRQoL (self-rated health state) was improved with ART use, including those with immunocompromised status, which may be relevant to the public sector ART program in South Africa. BioMed Central 2014-07-03 /pmc/articles/PMC4227123/ /pubmed/24990360 http://dx.doi.org/10.1186/1471-2458-14-676 Text en Copyright © 2014 Nglazi et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Nglazi, Mweete D West, Sacha J Dave, Joel A Levitt, Naomi S Lambert, Estelle V Quality of life in individuals living with HIV/AIDS attending a public sector antiretroviral service in Cape Town, South Africa |
title | Quality of life in individuals living with HIV/AIDS attending a public sector antiretroviral service in Cape Town, South Africa |
title_full | Quality of life in individuals living with HIV/AIDS attending a public sector antiretroviral service in Cape Town, South Africa |
title_fullStr | Quality of life in individuals living with HIV/AIDS attending a public sector antiretroviral service in Cape Town, South Africa |
title_full_unstemmed | Quality of life in individuals living with HIV/AIDS attending a public sector antiretroviral service in Cape Town, South Africa |
title_short | Quality of life in individuals living with HIV/AIDS attending a public sector antiretroviral service in Cape Town, South Africa |
title_sort | quality of life in individuals living with hiv/aids attending a public sector antiretroviral service in cape town, south africa |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4227123/ https://www.ncbi.nlm.nih.gov/pubmed/24990360 http://dx.doi.org/10.1186/1471-2458-14-676 |
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