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Circulating RNA Molecules as Biomarkers in Liver Disease

Liver disease is a major cause of morbidity and mortality worldwide. As in other fields of medicine, there is a stringent need for non-invasive markers to improve patient diagnostics, monitoring and prognostic ability in liver pathology. Cell-free circulating RNA molecules have been recently acknowl...

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Autores principales: Enache, Liviu S., Enache, Elena L., Ramière, Christophe, Diaz, Olivier, Bancu, Ligia, Sin, Anca, André, Patrice
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4227182/
https://www.ncbi.nlm.nih.gov/pubmed/25272224
http://dx.doi.org/10.3390/ijms151017644
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author Enache, Liviu S.
Enache, Elena L.
Ramière, Christophe
Diaz, Olivier
Bancu, Ligia
Sin, Anca
André, Patrice
author_facet Enache, Liviu S.
Enache, Elena L.
Ramière, Christophe
Diaz, Olivier
Bancu, Ligia
Sin, Anca
André, Patrice
author_sort Enache, Liviu S.
collection PubMed
description Liver disease is a major cause of morbidity and mortality worldwide. As in other fields of medicine, there is a stringent need for non-invasive markers to improve patient diagnostics, monitoring and prognostic ability in liver pathology. Cell-free circulating RNA molecules have been recently acknowledged as an important source of potential medical biomarkers. However, many aspects related to the biology of these molecules remain to be elucidated. In this review, we summarize current concepts related to the origin, transportation and possible functions of cell-free RNA. We outline current development of extracellular RNA-based biomarkers in the main forms of non-inherited liver disease: chronic viral hepatitis, hepatocellular carcinoma, non-alcoholic fatty liver, hepato-toxicity, and liver transplantation. Despite recent technological advances, the lack of standardization in the assessment of these markers makes their adoption into clinical practice difficult. We thus finally review the main factors influencing quantification of circulating RNA. These factors should be considered in the reporting and interpretation of current findings, as well as in the proper planning of future studies, to improve reliability and reproducibility of results.
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spelling pubmed-42271822014-11-12 Circulating RNA Molecules as Biomarkers in Liver Disease Enache, Liviu S. Enache, Elena L. Ramière, Christophe Diaz, Olivier Bancu, Ligia Sin, Anca André, Patrice Int J Mol Sci Review Liver disease is a major cause of morbidity and mortality worldwide. As in other fields of medicine, there is a stringent need for non-invasive markers to improve patient diagnostics, monitoring and prognostic ability in liver pathology. Cell-free circulating RNA molecules have been recently acknowledged as an important source of potential medical biomarkers. However, many aspects related to the biology of these molecules remain to be elucidated. In this review, we summarize current concepts related to the origin, transportation and possible functions of cell-free RNA. We outline current development of extracellular RNA-based biomarkers in the main forms of non-inherited liver disease: chronic viral hepatitis, hepatocellular carcinoma, non-alcoholic fatty liver, hepato-toxicity, and liver transplantation. Despite recent technological advances, the lack of standardization in the assessment of these markers makes their adoption into clinical practice difficult. We thus finally review the main factors influencing quantification of circulating RNA. These factors should be considered in the reporting and interpretation of current findings, as well as in the proper planning of future studies, to improve reliability and reproducibility of results. MDPI 2014-09-30 /pmc/articles/PMC4227182/ /pubmed/25272224 http://dx.doi.org/10.3390/ijms151017644 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Enache, Liviu S.
Enache, Elena L.
Ramière, Christophe
Diaz, Olivier
Bancu, Ligia
Sin, Anca
André, Patrice
Circulating RNA Molecules as Biomarkers in Liver Disease
title Circulating RNA Molecules as Biomarkers in Liver Disease
title_full Circulating RNA Molecules as Biomarkers in Liver Disease
title_fullStr Circulating RNA Molecules as Biomarkers in Liver Disease
title_full_unstemmed Circulating RNA Molecules as Biomarkers in Liver Disease
title_short Circulating RNA Molecules as Biomarkers in Liver Disease
title_sort circulating rna molecules as biomarkers in liver disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4227182/
https://www.ncbi.nlm.nih.gov/pubmed/25272224
http://dx.doi.org/10.3390/ijms151017644
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