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Calcium Signaling and Meiotic Exit at Fertilization in Xenopus Egg

Calcium is a universal messenger that mediates egg activation at fertilization in all sexually reproducing species studied. However, signaling pathways leading to calcium generation and the mechanisms of calcium-induced exit from meiotic arrest vary substantially among species. Here, we review the p...

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Autores principales: Tokmakov, Alexander A., Stefanov, Vasily E., Iwasaki, Tetsushi, Sato, Ken-Ichi, Fukami, Yasuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4227238/
https://www.ncbi.nlm.nih.gov/pubmed/25322156
http://dx.doi.org/10.3390/ijms151018659
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author Tokmakov, Alexander A.
Stefanov, Vasily E.
Iwasaki, Tetsushi
Sato, Ken-Ichi
Fukami, Yasuo
author_facet Tokmakov, Alexander A.
Stefanov, Vasily E.
Iwasaki, Tetsushi
Sato, Ken-Ichi
Fukami, Yasuo
author_sort Tokmakov, Alexander A.
collection PubMed
description Calcium is a universal messenger that mediates egg activation at fertilization in all sexually reproducing species studied. However, signaling pathways leading to calcium generation and the mechanisms of calcium-induced exit from meiotic arrest vary substantially among species. Here, we review the pathways of calcium signaling and the mechanisms of meiotic exit at fertilization in the eggs of the established developmental model, African clawed frog, Xenopus laevis. We also discuss calcium involvement in the early fertilization-induced events in Xenopus egg, such as membrane depolarization, the increase in intracellular pH, cortical granule exocytosis, cortical contraction, contraction wave, cortical rotation, reformation of the nuclear envelope, sperm chromatin decondensation and sister chromatid segregation.
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spelling pubmed-42272382014-11-12 Calcium Signaling and Meiotic Exit at Fertilization in Xenopus Egg Tokmakov, Alexander A. Stefanov, Vasily E. Iwasaki, Tetsushi Sato, Ken-Ichi Fukami, Yasuo Int J Mol Sci Review Calcium is a universal messenger that mediates egg activation at fertilization in all sexually reproducing species studied. However, signaling pathways leading to calcium generation and the mechanisms of calcium-induced exit from meiotic arrest vary substantially among species. Here, we review the pathways of calcium signaling and the mechanisms of meiotic exit at fertilization in the eggs of the established developmental model, African clawed frog, Xenopus laevis. We also discuss calcium involvement in the early fertilization-induced events in Xenopus egg, such as membrane depolarization, the increase in intracellular pH, cortical granule exocytosis, cortical contraction, contraction wave, cortical rotation, reformation of the nuclear envelope, sperm chromatin decondensation and sister chromatid segregation. MDPI 2014-10-15 /pmc/articles/PMC4227238/ /pubmed/25322156 http://dx.doi.org/10.3390/ijms151018659 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Tokmakov, Alexander A.
Stefanov, Vasily E.
Iwasaki, Tetsushi
Sato, Ken-Ichi
Fukami, Yasuo
Calcium Signaling and Meiotic Exit at Fertilization in Xenopus Egg
title Calcium Signaling and Meiotic Exit at Fertilization in Xenopus Egg
title_full Calcium Signaling and Meiotic Exit at Fertilization in Xenopus Egg
title_fullStr Calcium Signaling and Meiotic Exit at Fertilization in Xenopus Egg
title_full_unstemmed Calcium Signaling and Meiotic Exit at Fertilization in Xenopus Egg
title_short Calcium Signaling and Meiotic Exit at Fertilization in Xenopus Egg
title_sort calcium signaling and meiotic exit at fertilization in xenopus egg
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4227238/
https://www.ncbi.nlm.nih.gov/pubmed/25322156
http://dx.doi.org/10.3390/ijms151018659
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