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Hemophagocytic Lymphohistiocytosis in Association with Primary Cutaneous Anaplastic Large Cell Lymphoma

Hemophagocytic lymphohistiocytosis (HLH) has a well known association with lymphomas, especially of T cell origin. Prognosis of lymphoma associated HLH is very poor, especially in T cell lymphomas; and, therefore, early diagnosis might alter the outcome. Though association of HLH with systemic anapl...

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Autores principales: Basheer, Aneesh, Padhi, Somanath, Nagarajan, Ramesh, Boopathy, Vinoth, Mookkappan, Sudhagar, Iqbal, Nayyar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4227362/
https://www.ncbi.nlm.nih.gov/pubmed/25405042
http://dx.doi.org/10.1155/2014/384123
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author Basheer, Aneesh
Padhi, Somanath
Nagarajan, Ramesh
Boopathy, Vinoth
Mookkappan, Sudhagar
Iqbal, Nayyar
author_facet Basheer, Aneesh
Padhi, Somanath
Nagarajan, Ramesh
Boopathy, Vinoth
Mookkappan, Sudhagar
Iqbal, Nayyar
author_sort Basheer, Aneesh
collection PubMed
description Hemophagocytic lymphohistiocytosis (HLH) has a well known association with lymphomas, especially of T cell origin. Prognosis of lymphoma associated HLH is very poor, especially in T cell lymphomas; and, therefore, early diagnosis might alter the outcome. Though association of HLH with systemic anaplastic large cell lymphoma (ALCL) is known, its occurrence in primary cutaneous ALCL (C-ALCL) is distinctly rare. We aim to describe a case of C-ALCL (anaplastic lymphoma kinase (ALK)−) in an elderly male who succumbed to the complication of associated HLH, which was possibly triggered by coexistent virus infection. We briefly present the literatures on lymphoma associated HLH and discuss the histopathological differentials of cutaneous CD30+ lymphoproliferative disorders. We do suggest that HLH may pose diagnostic challenges in the evaluation of an underlying lymphoma and hence warrants proper evaluation for the underlying etiologies and/or triggering factors.
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spelling pubmed-42273622014-11-17 Hemophagocytic Lymphohistiocytosis in Association with Primary Cutaneous Anaplastic Large Cell Lymphoma Basheer, Aneesh Padhi, Somanath Nagarajan, Ramesh Boopathy, Vinoth Mookkappan, Sudhagar Iqbal, Nayyar Case Rep Hematol Case Report Hemophagocytic lymphohistiocytosis (HLH) has a well known association with lymphomas, especially of T cell origin. Prognosis of lymphoma associated HLH is very poor, especially in T cell lymphomas; and, therefore, early diagnosis might alter the outcome. Though association of HLH with systemic anaplastic large cell lymphoma (ALCL) is known, its occurrence in primary cutaneous ALCL (C-ALCL) is distinctly rare. We aim to describe a case of C-ALCL (anaplastic lymphoma kinase (ALK)−) in an elderly male who succumbed to the complication of associated HLH, which was possibly triggered by coexistent virus infection. We briefly present the literatures on lymphoma associated HLH and discuss the histopathological differentials of cutaneous CD30+ lymphoproliferative disorders. We do suggest that HLH may pose diagnostic challenges in the evaluation of an underlying lymphoma and hence warrants proper evaluation for the underlying etiologies and/or triggering factors. Hindawi Publishing Corporation 2014 2014-10-28 /pmc/articles/PMC4227362/ /pubmed/25405042 http://dx.doi.org/10.1155/2014/384123 Text en Copyright © 2014 Aneesh Basheer et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Basheer, Aneesh
Padhi, Somanath
Nagarajan, Ramesh
Boopathy, Vinoth
Mookkappan, Sudhagar
Iqbal, Nayyar
Hemophagocytic Lymphohistiocytosis in Association with Primary Cutaneous Anaplastic Large Cell Lymphoma
title Hemophagocytic Lymphohistiocytosis in Association with Primary Cutaneous Anaplastic Large Cell Lymphoma
title_full Hemophagocytic Lymphohistiocytosis in Association with Primary Cutaneous Anaplastic Large Cell Lymphoma
title_fullStr Hemophagocytic Lymphohistiocytosis in Association with Primary Cutaneous Anaplastic Large Cell Lymphoma
title_full_unstemmed Hemophagocytic Lymphohistiocytosis in Association with Primary Cutaneous Anaplastic Large Cell Lymphoma
title_short Hemophagocytic Lymphohistiocytosis in Association with Primary Cutaneous Anaplastic Large Cell Lymphoma
title_sort hemophagocytic lymphohistiocytosis in association with primary cutaneous anaplastic large cell lymphoma
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4227362/
https://www.ncbi.nlm.nih.gov/pubmed/25405042
http://dx.doi.org/10.1155/2014/384123
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