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Prognostic Significance of MicroRNA-375 Downregulation in Solid Tumors: A Meta-Analysis

Objective. Recently, many studies have shown that microRNAs (miRNA) exhibit altered expression in various cancers and may play an important role as prognostic biomarker of cancers. We performed a meta-analysis to evaluate the impact of miR-375 expression in solid tumors on patients' overall sur...

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Autores principales: Shao, Yingjie, Geng, Yiting, Gu, Wendong, Huang, Jin, Ning, Zhonghua, Pei, Honglei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4227452/
https://www.ncbi.nlm.nih.gov/pubmed/25404787
http://dx.doi.org/10.1155/2014/626185
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author Shao, Yingjie
Geng, Yiting
Gu, Wendong
Huang, Jin
Ning, Zhonghua
Pei, Honglei
author_facet Shao, Yingjie
Geng, Yiting
Gu, Wendong
Huang, Jin
Ning, Zhonghua
Pei, Honglei
author_sort Shao, Yingjie
collection PubMed
description Objective. Recently, many studies have shown that microRNAs (miRNA) exhibit altered expression in various cancers and may play an important role as prognostic biomarker of cancers. We performed a meta-analysis to evaluate the impact of miR-375 expression in solid tumors on patients' overall survival (OS). Methods. Studies were identified by searching PubMed, Embace, and Cochrane Library (last search update was in May 2014) and were assessed by further quality evaluation. The pooled hazard ratios (HRs) with 95% confidence intervals (CIs) for total and stratified analyses were calculated to investigate the association between miR-375 expression and cancer patients OS. Results. Our analysis results indicated that downregulation of miR-375 predicted poor OS (HR = 1.91, 95% CI 1.48–2.45, P < 0.001). Subgroup analyses showed that lower expression of miR-375 was significantly related with poor OS in patients with esophageal carcinoma (HR = 2.24, 95% CI 1.69–2.96, P < 0.001) and non-small-cell lung cancer (NSCLC) (HR = 1.71, 95% CI 1.31–2.24, P < 0.001). Conclusions. The findings from this meta-analysis suggest that miR-375 expression is associated with OS of patients with malignant tumors and could be a useful clinical prognostic biomarker.
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spelling pubmed-42274522014-11-17 Prognostic Significance of MicroRNA-375 Downregulation in Solid Tumors: A Meta-Analysis Shao, Yingjie Geng, Yiting Gu, Wendong Huang, Jin Ning, Zhonghua Pei, Honglei Dis Markers Review Article Objective. Recently, many studies have shown that microRNAs (miRNA) exhibit altered expression in various cancers and may play an important role as prognostic biomarker of cancers. We performed a meta-analysis to evaluate the impact of miR-375 expression in solid tumors on patients' overall survival (OS). Methods. Studies were identified by searching PubMed, Embace, and Cochrane Library (last search update was in May 2014) and were assessed by further quality evaluation. The pooled hazard ratios (HRs) with 95% confidence intervals (CIs) for total and stratified analyses were calculated to investigate the association between miR-375 expression and cancer patients OS. Results. Our analysis results indicated that downregulation of miR-375 predicted poor OS (HR = 1.91, 95% CI 1.48–2.45, P < 0.001). Subgroup analyses showed that lower expression of miR-375 was significantly related with poor OS in patients with esophageal carcinoma (HR = 2.24, 95% CI 1.69–2.96, P < 0.001) and non-small-cell lung cancer (NSCLC) (HR = 1.71, 95% CI 1.31–2.24, P < 0.001). Conclusions. The findings from this meta-analysis suggest that miR-375 expression is associated with OS of patients with malignant tumors and could be a useful clinical prognostic biomarker. Hindawi Publishing Corporation 2014 2014-10-23 /pmc/articles/PMC4227452/ /pubmed/25404787 http://dx.doi.org/10.1155/2014/626185 Text en Copyright © 2014 Yingjie Shao et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Shao, Yingjie
Geng, Yiting
Gu, Wendong
Huang, Jin
Ning, Zhonghua
Pei, Honglei
Prognostic Significance of MicroRNA-375 Downregulation in Solid Tumors: A Meta-Analysis
title Prognostic Significance of MicroRNA-375 Downregulation in Solid Tumors: A Meta-Analysis
title_full Prognostic Significance of MicroRNA-375 Downregulation in Solid Tumors: A Meta-Analysis
title_fullStr Prognostic Significance of MicroRNA-375 Downregulation in Solid Tumors: A Meta-Analysis
title_full_unstemmed Prognostic Significance of MicroRNA-375 Downregulation in Solid Tumors: A Meta-Analysis
title_short Prognostic Significance of MicroRNA-375 Downregulation in Solid Tumors: A Meta-Analysis
title_sort prognostic significance of microrna-375 downregulation in solid tumors: a meta-analysis
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4227452/
https://www.ncbi.nlm.nih.gov/pubmed/25404787
http://dx.doi.org/10.1155/2014/626185
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