A Universal Isocyanide for Diverse Heterocycle Syntheses

[Image: see text] Novel scaffolds are of uttermost importance for the discovery of functional material. Three different heterocyclic scaffolds easily accessible from isocyanoacetaldehyde dimethylacetal 1 by multicomponent reaction (MCR) are described. They can be efficiently synthesized by a Ugi tet...

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Detalles Bibliográficos
Autores principales: Patil, Pravin, Khoury, Kareem, Herdtweck, Eberhardt, Dömling, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4227542/
https://www.ncbi.nlm.nih.gov/pubmed/25351886
http://dx.doi.org/10.1021/ol5024882
Descripción
Sumario:[Image: see text] Novel scaffolds are of uttermost importance for the discovery of functional material. Three different heterocyclic scaffolds easily accessible from isocyanoacetaldehyde dimethylacetal 1 by multicomponent reaction (MCR) are described. They can be efficiently synthesized by a Ugi tetrazole multicomponent reaction of 1. We discuss the synthesis, 3D structures, and other physicochemical properties.

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