A Universal Isocyanide for Diverse Heterocycle Syntheses

[Image: see text] Novel scaffolds are of uttermost importance for the discovery of functional material. Three different heterocyclic scaffolds easily accessible from isocyanoacetaldehyde dimethylacetal 1 by multicomponent reaction (MCR) are described. They can be efficiently synthesized by a Ugi tet...

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Autores principales: Patil, Pravin, Khoury, Kareem, Herdtweck, Eberhardt, Dömling, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4227542/
https://www.ncbi.nlm.nih.gov/pubmed/25351886
http://dx.doi.org/10.1021/ol5024882
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author Patil, Pravin
Khoury, Kareem
Herdtweck, Eberhardt
Dömling, Alexander
author_facet Patil, Pravin
Khoury, Kareem
Herdtweck, Eberhardt
Dömling, Alexander
author_sort Patil, Pravin
collection PubMed
description [Image: see text] Novel scaffolds are of uttermost importance for the discovery of functional material. Three different heterocyclic scaffolds easily accessible from isocyanoacetaldehyde dimethylacetal 1 by multicomponent reaction (MCR) are described. They can be efficiently synthesized by a Ugi tetrazole multicomponent reaction of 1. We discuss the synthesis, 3D structures, and other physicochemical properties.
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spelling pubmed-42275422015-10-29 A Universal Isocyanide for Diverse Heterocycle Syntheses Patil, Pravin Khoury, Kareem Herdtweck, Eberhardt Dömling, Alexander Org Lett [Image: see text] Novel scaffolds are of uttermost importance for the discovery of functional material. Three different heterocyclic scaffolds easily accessible from isocyanoacetaldehyde dimethylacetal 1 by multicomponent reaction (MCR) are described. They can be efficiently synthesized by a Ugi tetrazole multicomponent reaction of 1. We discuss the synthesis, 3D structures, and other physicochemical properties. American Chemical Society 2014-10-29 2014-11-07 /pmc/articles/PMC4227542/ /pubmed/25351886 http://dx.doi.org/10.1021/ol5024882 Text en Copyright © 2014 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
spellingShingle Patil, Pravin
Khoury, Kareem
Herdtweck, Eberhardt
Dömling, Alexander
A Universal Isocyanide for Diverse Heterocycle Syntheses
title A Universal Isocyanide for Diverse Heterocycle Syntheses
title_full A Universal Isocyanide for Diverse Heterocycle Syntheses
title_fullStr A Universal Isocyanide for Diverse Heterocycle Syntheses
title_full_unstemmed A Universal Isocyanide for Diverse Heterocycle Syntheses
title_short A Universal Isocyanide for Diverse Heterocycle Syntheses
title_sort universal isocyanide for diverse heterocycle syntheses
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4227542/
https://www.ncbi.nlm.nih.gov/pubmed/25351886
http://dx.doi.org/10.1021/ol5024882
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