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Lactose as a “Trojan Horse” for Quantum Dot Cell Transport**

A series of glycan-coated quantum dots were prepared to probe the effect of glycan presentation in intracellular localization in HeLa and SV40 epithelial cells. We show that glycan density mostly impacts on cell toxicity, whereas glycan type affects the cell uptake and intracellular localization. Mo...

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Detalles Bibliográficos
Autores principales: Benito-Alifonso, David, Tremel, Shirley, Hou, Bo, Lockyear, Harriet, Mantell, Judith, Fermin, David J, Verkade, Paul, Berry, Monica, Galan, M Carmen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: WILEY-VCH Verlag 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4227560/
https://www.ncbi.nlm.nih.gov/pubmed/24311369
http://dx.doi.org/10.1002/anie.201307232
Descripción
Sumario:A series of glycan-coated quantum dots were prepared to probe the effect of glycan presentation in intracellular localization in HeLa and SV40 epithelial cells. We show that glycan density mostly impacts on cell toxicity, whereas glycan type affects the cell uptake and intracellular localization. Moreover, we show that lactose can act as a “Trojan horse” on bi-functionalized QDs to help intracellular delivery of other non-internalizable glycan moieties and largely avoid the endosomal/lysosomal degradative pathway.