Lactose as a “Trojan Horse” for Quantum Dot Cell Transport**

A series of glycan-coated quantum dots were prepared to probe the effect of glycan presentation in intracellular localization in HeLa and SV40 epithelial cells. We show that glycan density mostly impacts on cell toxicity, whereas glycan type affects the cell uptake and intracellular localization. Mo...

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Detalles Bibliográficos
Autores principales: Benito-Alifonso, David, Tremel, Shirley, Hou, Bo, Lockyear, Harriet, Mantell, Judith, Fermin, David J, Verkade, Paul, Berry, Monica, Galan, M Carmen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: WILEY-VCH Verlag 2014
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4227560/
https://www.ncbi.nlm.nih.gov/pubmed/24311369
http://dx.doi.org/10.1002/anie.201307232
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author Benito-Alifonso, David
Tremel, Shirley
Hou, Bo
Lockyear, Harriet
Mantell, Judith
Fermin, David J
Verkade, Paul
Berry, Monica
Galan, M Carmen
author_facet Benito-Alifonso, David
Tremel, Shirley
Hou, Bo
Lockyear, Harriet
Mantell, Judith
Fermin, David J
Verkade, Paul
Berry, Monica
Galan, M Carmen
author_sort Benito-Alifonso, David
collection PubMed
description A series of glycan-coated quantum dots were prepared to probe the effect of glycan presentation in intracellular localization in HeLa and SV40 epithelial cells. We show that glycan density mostly impacts on cell toxicity, whereas glycan type affects the cell uptake and intracellular localization. Moreover, we show that lactose can act as a “Trojan horse” on bi-functionalized QDs to help intracellular delivery of other non-internalizable glycan moieties and largely avoid the endosomal/lysosomal degradative pathway.
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spelling pubmed-42275602014-12-22 Lactose as a “Trojan Horse” for Quantum Dot Cell Transport** Benito-Alifonso, David Tremel, Shirley Hou, Bo Lockyear, Harriet Mantell, Judith Fermin, David J Verkade, Paul Berry, Monica Galan, M Carmen Angew Chem Int Ed Engl Communications A series of glycan-coated quantum dots were prepared to probe the effect of glycan presentation in intracellular localization in HeLa and SV40 epithelial cells. We show that glycan density mostly impacts on cell toxicity, whereas glycan type affects the cell uptake and intracellular localization. Moreover, we show that lactose can act as a “Trojan horse” on bi-functionalized QDs to help intracellular delivery of other non-internalizable glycan moieties and largely avoid the endosomal/lysosomal degradative pathway. WILEY-VCH Verlag 2014-01-13 2013-12-05 /pmc/articles/PMC4227560/ /pubmed/24311369 http://dx.doi.org/10.1002/anie.201307232 Text en © 2014 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA. http://creativecommons.org/licenses/by/3.0/ This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Communications
Benito-Alifonso, David
Tremel, Shirley
Hou, Bo
Lockyear, Harriet
Mantell, Judith
Fermin, David J
Verkade, Paul
Berry, Monica
Galan, M Carmen
Lactose as a “Trojan Horse” for Quantum Dot Cell Transport**
title Lactose as a “Trojan Horse” for Quantum Dot Cell Transport**
title_full Lactose as a “Trojan Horse” for Quantum Dot Cell Transport**
title_fullStr Lactose as a “Trojan Horse” for Quantum Dot Cell Transport**
title_full_unstemmed Lactose as a “Trojan Horse” for Quantum Dot Cell Transport**
title_short Lactose as a “Trojan Horse” for Quantum Dot Cell Transport**
title_sort lactose as a “trojan horse” for quantum dot cell transport**
topic Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4227560/
https://www.ncbi.nlm.nih.gov/pubmed/24311369
http://dx.doi.org/10.1002/anie.201307232
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