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A Regio- and Stereoselective ω-Transaminase/Monoamine Oxidase Cascade for the Synthesis of Chiral 2,5-Disubstituted Pyrrolidines**
Biocatalytic approaches to the synthesis of optically pure chiral amines, starting from simple achiral building blocks, are highly desirable because such motifs are present in a wide variety of important natural products and pharmaceutical compounds. Herein, a novel one-pot ω-transaminase (TA)/monoa...
Autores principales: | O'Reilly, Elaine, Iglesias, Cesar, Ghislieri, Diego, Hopwood, Jennifer, Galman, James L, Lloyd, Richard C, Turner, Nicholas J |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
WILEY-VCH Verlag
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4227563/ https://www.ncbi.nlm.nih.gov/pubmed/24478044 http://dx.doi.org/10.1002/anie.201309208 |
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