Association of FKBP51 with Priming of Autophagy Pathways and Mediation of Antidepressant Treatment Response: Evidence in Cells, Mice, and Humans

BACKGROUND: FK506 binding protein 51 (FKBP51) is an Hsp90 co-chaperone and regulator of the glucocorticoid receptor, and consequently of stress physiology. Clinical studies suggest a genetic link between FKBP51 and antidepressant response in mood disorders; however, the underlying mechanisms remain...

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Detalles Bibliográficos
Autores principales: Gassen, Nils C., Hartmann, Jakob, Zschocke, Jürgen, Stepan, Jens, Hafner, Kathrin, Zellner, Andreas, Kirmeier, Thomas, Kollmannsberger, Lorenz, Wagner, Klaus V., Dedic, Nina, Balsevich, Georgia, Deussing, Jan M., Kloiber, Stefan, Lucae, Susanne, Holsboer, Florian, Eder, Matthias, Uhr, Manfred, Ising, Marcus, Schmidt, Mathias V., Rein, Theo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4227651/
https://www.ncbi.nlm.nih.gov/pubmed/25386878
http://dx.doi.org/10.1371/journal.pmed.1001755

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