Enantioselective Intramolecular C–H Insertion Reactions of Donor–Donor Metal Carbenoids

[Image: see text] The first asymmetric insertion reactions of donor–donor carbenoids, i.e., those with no pendant electron-withdrawing groups, are reported. This process enables the synthesis of densely substituted benzodihydrofurans with high levels of enantio- and diastereoselectivity. Preliminary...

Descripción completa

Detalles Bibliográficos
Autores principales: Soldi, Cristian, Lamb, Kellan N., Squitieri, Richard A., González-López, Marcos, Di Maso, Michael J., Shaw, Jared T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4227726/
https://www.ncbi.nlm.nih.gov/pubmed/25308822
http://dx.doi.org/10.1021/ja508586t
Descripción
Sumario:[Image: see text] The first asymmetric insertion reactions of donor–donor carbenoids, i.e., those with no pendant electron-withdrawing groups, are reported. This process enables the synthesis of densely substituted benzodihydrofurans with high levels of enantio- and diastereoselectivity. Preliminary results show similar efficiency in the preparation of indanes. This new method is used in the first enantioselective synthesis of an oligoresveratrol natural product (E-δ-viniferin).

Ejemplares similares