Checkpoint-dependent and independent roles of the Werner syndrome protein in preserving genome integrity in response to mild replication stress

Werner syndrome (WS) is a human chromosomal instability disorder associated with cancer predisposition and caused by mutations in the WRN gene. WRN helicase activity is crucial in limiting breakage at common fragile sites (CFS), which are the preferential targets of genome instability in precancerou...

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Detalles Bibliográficos
Autores principales: Basile, Giorgia, Leuzzi, Giuseppe, Pichierri, Pietro, Franchitto, Annapaola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4227752/
https://www.ncbi.nlm.nih.gov/pubmed/25352544
http://dx.doi.org/10.1093/nar/gku1022

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