Cargando…
Global identification of target recognition and cleavage by the Microprocessor in human ES cells
The Microprocessor plays an essential role in canonical miRNA biogenesis by facilitating cleavage of stem-loop structures in primary transcripts to yield pre-miRNAs. Although miRNA biogenesis has been extensively studied through biochemical and molecular genetic approaches, it has yet to be addresse...
Autores principales: | Seong, Youngmo, Lim, Do-Hwan, Kim, Augustine, Seo, Jae Hong, Lee, Young Sik, Song, Hoseok, Kwon, Young-Soo |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4227787/ https://www.ncbi.nlm.nih.gov/pubmed/25326327 http://dx.doi.org/10.1093/nar/gku957 |
Ejemplares similares
-
A novel role for GSK3β as a modulator of Drosha microprocessor activity and MicroRNA biogenesis
por: Fletcher, Claire E., et al.
Publicado: (2017) -
Cleavage of model substrates by archaeal RNase P: role of protein cofactors in cleavage-site selection
por: Sinapah, Sylvie, et al.
Publicado: (2011) -
Global analysis of the mammalian RNA degradome reveals widespread miRNA-dependent and miRNA-independent endonucleolytic cleavage
por: Bracken, Cameron P., et al.
Publicado: (2011) -
Structural insights into target DNA recognition and cleavage by the CRISPR-Cas12c1 system
por: Zhang, Bo, et al.
Publicado: (2022) -
On the mechanism of RNA phosphodiester backbone cleavage in the absence of solvent
por: Riml, Christian, et al.
Publicado: (2015)