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New tools provide a second look at HDV ribozyme structure, dynamics and cleavage

The hepatitis delta virus (HDV) ribozyme is a self-cleaving RNA enzyme essential for processing viral transcripts during rolling circle viral replication. The first crystal structure of the cleaved ribozyme was solved in 1998, followed by structures of uncleaved, mutant-inhibited and ion-complexed f...

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Detalles Bibliográficos
Autores principales:	Kapral, Gary J., Jain, Swati, Noeske, Jonas, Doudna, Jennifer A., Richardson, David C., Richardson, Jane S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2014
Materias:	RNA
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4227795/ https://www.ncbi.nlm.nih.gov/pubmed/25326328 http://dx.doi.org/10.1093/nar/gku992

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