Cargando…

Therapeutic effects of isoflavones on impaired salivary secretion

Dry mouth, which is characterized by decreased salivation, has a number of causes; the involvement of estrogen has been suggested as symptoms typically develop in middle-aged females. However, there is a lack of consensus regarding the treatment of this condition. Soy isoflavones, a subgroup of flav...

Descripción completa

Detalles Bibliográficos
Autores principales: Ryo, Koufuchi, Takahashi, Ayako, Tamaki, Yoh, Ohnishi-Kameyama, Mayumi, Inoue, Hiroko, Saito, Ichiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: the Society for Free Radical Research Japan 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4227830/
https://www.ncbi.nlm.nih.gov/pubmed/25411521
http://dx.doi.org/10.3164/jcbn.14-49
_version_ 1782343883808571392
author Ryo, Koufuchi
Takahashi, Ayako
Tamaki, Yoh
Ohnishi-Kameyama, Mayumi
Inoue, Hiroko
Saito, Ichiro
author_facet Ryo, Koufuchi
Takahashi, Ayako
Tamaki, Yoh
Ohnishi-Kameyama, Mayumi
Inoue, Hiroko
Saito, Ichiro
author_sort Ryo, Koufuchi
collection PubMed
description Dry mouth, which is characterized by decreased salivation, has a number of causes; the involvement of estrogen has been suggested as symptoms typically develop in middle-aged females. However, there is a lack of consensus regarding the treatment of this condition. Soy isoflavones, a subgroup of flavonoids, are abundantly found in the soy germ. They are thought to exert a number of effects by specifically binding to estrogen receptors due to their structural similarity to estrogen. Recently, soy isoflavones have been found to exert antioxidant effects, ameliorating disorders caused by reactive oxygen/free radicals. Based on these observations, the effects of soybean isoflavones on impaired salivary secretion were studied in patients with dry mouth. Soy isoflavone aglycones were administered at 25 mg per day to 15 subjects with an average age of 67.9 ± 8.0 years for 2 months, and salivary secretion was analyzed. The results showed a significant improvement based on the saliva flow rate and self-completed questionnaire, thus suggesting the usefulness of isoflavones in improving the symptoms of salivary gland hypofunction.
format Online
Article
Text
id pubmed-4227830
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher the Society for Free Radical Research Japan
record_format MEDLINE/PubMed
spelling pubmed-42278302014-11-19 Therapeutic effects of isoflavones on impaired salivary secretion Ryo, Koufuchi Takahashi, Ayako Tamaki, Yoh Ohnishi-Kameyama, Mayumi Inoue, Hiroko Saito, Ichiro J Clin Biochem Nutr Original Article Dry mouth, which is characterized by decreased salivation, has a number of causes; the involvement of estrogen has been suggested as symptoms typically develop in middle-aged females. However, there is a lack of consensus regarding the treatment of this condition. Soy isoflavones, a subgroup of flavonoids, are abundantly found in the soy germ. They are thought to exert a number of effects by specifically binding to estrogen receptors due to their structural similarity to estrogen. Recently, soy isoflavones have been found to exert antioxidant effects, ameliorating disorders caused by reactive oxygen/free radicals. Based on these observations, the effects of soybean isoflavones on impaired salivary secretion were studied in patients with dry mouth. Soy isoflavone aglycones were administered at 25 mg per day to 15 subjects with an average age of 67.9 ± 8.0 years for 2 months, and salivary secretion was analyzed. The results showed a significant improvement based on the saliva flow rate and self-completed questionnaire, thus suggesting the usefulness of isoflavones in improving the symptoms of salivary gland hypofunction. the Society for Free Radical Research Japan 2014-11 2014-09-30 /pmc/articles/PMC4227830/ /pubmed/25411521 http://dx.doi.org/10.3164/jcbn.14-49 Text en Copyright © 2014 JCBN This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Ryo, Koufuchi
Takahashi, Ayako
Tamaki, Yoh
Ohnishi-Kameyama, Mayumi
Inoue, Hiroko
Saito, Ichiro
Therapeutic effects of isoflavones on impaired salivary secretion
title Therapeutic effects of isoflavones on impaired salivary secretion
title_full Therapeutic effects of isoflavones on impaired salivary secretion
title_fullStr Therapeutic effects of isoflavones on impaired salivary secretion
title_full_unstemmed Therapeutic effects of isoflavones on impaired salivary secretion
title_short Therapeutic effects of isoflavones on impaired salivary secretion
title_sort therapeutic effects of isoflavones on impaired salivary secretion
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4227830/
https://www.ncbi.nlm.nih.gov/pubmed/25411521
http://dx.doi.org/10.3164/jcbn.14-49
work_keys_str_mv AT ryokoufuchi therapeuticeffectsofisoflavonesonimpairedsalivarysecretion
AT takahashiayako therapeuticeffectsofisoflavonesonimpairedsalivarysecretion
AT tamakiyoh therapeuticeffectsofisoflavonesonimpairedsalivarysecretion
AT ohnishikameyamamayumi therapeuticeffectsofisoflavonesonimpairedsalivarysecretion
AT inouehiroko therapeuticeffectsofisoflavonesonimpairedsalivarysecretion
AT saitoichiro therapeuticeffectsofisoflavonesonimpairedsalivarysecretion