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Therapeutic effects of isoflavones on impaired salivary secretion
Dry mouth, which is characterized by decreased salivation, has a number of causes; the involvement of estrogen has been suggested as symptoms typically develop in middle-aged females. However, there is a lack of consensus regarding the treatment of this condition. Soy isoflavones, a subgroup of flav...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
the Society for Free Radical Research Japan
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4227830/ https://www.ncbi.nlm.nih.gov/pubmed/25411521 http://dx.doi.org/10.3164/jcbn.14-49 |
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author | Ryo, Koufuchi Takahashi, Ayako Tamaki, Yoh Ohnishi-Kameyama, Mayumi Inoue, Hiroko Saito, Ichiro |
author_facet | Ryo, Koufuchi Takahashi, Ayako Tamaki, Yoh Ohnishi-Kameyama, Mayumi Inoue, Hiroko Saito, Ichiro |
author_sort | Ryo, Koufuchi |
collection | PubMed |
description | Dry mouth, which is characterized by decreased salivation, has a number of causes; the involvement of estrogen has been suggested as symptoms typically develop in middle-aged females. However, there is a lack of consensus regarding the treatment of this condition. Soy isoflavones, a subgroup of flavonoids, are abundantly found in the soy germ. They are thought to exert a number of effects by specifically binding to estrogen receptors due to their structural similarity to estrogen. Recently, soy isoflavones have been found to exert antioxidant effects, ameliorating disorders caused by reactive oxygen/free radicals. Based on these observations, the effects of soybean isoflavones on impaired salivary secretion were studied in patients with dry mouth. Soy isoflavone aglycones were administered at 25 mg per day to 15 subjects with an average age of 67.9 ± 8.0 years for 2 months, and salivary secretion was analyzed. The results showed a significant improvement based on the saliva flow rate and self-completed questionnaire, thus suggesting the usefulness of isoflavones in improving the symptoms of salivary gland hypofunction. |
format | Online Article Text |
id | pubmed-4227830 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | the Society for Free Radical Research Japan |
record_format | MEDLINE/PubMed |
spelling | pubmed-42278302014-11-19 Therapeutic effects of isoflavones on impaired salivary secretion Ryo, Koufuchi Takahashi, Ayako Tamaki, Yoh Ohnishi-Kameyama, Mayumi Inoue, Hiroko Saito, Ichiro J Clin Biochem Nutr Original Article Dry mouth, which is characterized by decreased salivation, has a number of causes; the involvement of estrogen has been suggested as symptoms typically develop in middle-aged females. However, there is a lack of consensus regarding the treatment of this condition. Soy isoflavones, a subgroup of flavonoids, are abundantly found in the soy germ. They are thought to exert a number of effects by specifically binding to estrogen receptors due to their structural similarity to estrogen. Recently, soy isoflavones have been found to exert antioxidant effects, ameliorating disorders caused by reactive oxygen/free radicals. Based on these observations, the effects of soybean isoflavones on impaired salivary secretion were studied in patients with dry mouth. Soy isoflavone aglycones were administered at 25 mg per day to 15 subjects with an average age of 67.9 ± 8.0 years for 2 months, and salivary secretion was analyzed. The results showed a significant improvement based on the saliva flow rate and self-completed questionnaire, thus suggesting the usefulness of isoflavones in improving the symptoms of salivary gland hypofunction. the Society for Free Radical Research Japan 2014-11 2014-09-30 /pmc/articles/PMC4227830/ /pubmed/25411521 http://dx.doi.org/10.3164/jcbn.14-49 Text en Copyright © 2014 JCBN This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Ryo, Koufuchi Takahashi, Ayako Tamaki, Yoh Ohnishi-Kameyama, Mayumi Inoue, Hiroko Saito, Ichiro Therapeutic effects of isoflavones on impaired salivary secretion |
title | Therapeutic effects of isoflavones on impaired salivary secretion |
title_full | Therapeutic effects of isoflavones on impaired salivary secretion |
title_fullStr | Therapeutic effects of isoflavones on impaired salivary secretion |
title_full_unstemmed | Therapeutic effects of isoflavones on impaired salivary secretion |
title_short | Therapeutic effects of isoflavones on impaired salivary secretion |
title_sort | therapeutic effects of isoflavones on impaired salivary secretion |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4227830/ https://www.ncbi.nlm.nih.gov/pubmed/25411521 http://dx.doi.org/10.3164/jcbn.14-49 |
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