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Functional Vascular Changes of the Kidney during Pregnancy in Animals: A Systematic Review and Meta-Analysis

Renal vascular responses to pregnancy have frequently been studied, by investigating renal vascular resistance (RVR), renal flow, glomerular filtration rate (GFR), and renal artery responses to stimuli. Nonetheless, several questions remain: 1. Which vasodilator pathways are activated and to what ex...

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Autores principales: van Drongelen, Joris, de Vries, Rob, Lotgering, Frederik K., Smits, Paul, Spaanderman, Marc E. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4227845/
https://www.ncbi.nlm.nih.gov/pubmed/25386682
http://dx.doi.org/10.1371/journal.pone.0112084
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author van Drongelen, Joris
de Vries, Rob
Lotgering, Frederik K.
Smits, Paul
Spaanderman, Marc E. A.
author_facet van Drongelen, Joris
de Vries, Rob
Lotgering, Frederik K.
Smits, Paul
Spaanderman, Marc E. A.
author_sort van Drongelen, Joris
collection PubMed
description Renal vascular responses to pregnancy have frequently been studied, by investigating renal vascular resistance (RVR), renal flow, glomerular filtration rate (GFR), and renal artery responses to stimuli. Nonetheless, several questions remain: 1. Which vasodilator pathways are activated and to what extent do they affect RVR, renal flow and GFR across species, strains and gestational ages, 2. Are these changes dependent on renal artery adaptation, 3. At which cellular level does pregnancy affect the involved pathways? In an attempt to answer the questions raised, we performed a systematic review and meta-analysis on animal data. We included 37 studies (116 responses). At mid-gestation, RVR and GFR change to a similar degree across species and strains, accompanied by variable change in renal flow. At least in rats, changes depend on NO activation. At late gestation, changes in RVR, renal flow and GFR vary between species and strains. In rats, these changes are effectuated by sympathetic stimulation. Overall, renal artery responsiveness to stimuli is unaffected by pregnancy, except for Sprague Dawley rats in which pregnancy enhances renal artery vascular compliance and reduces renal artery myogenic reactivity. Our meta-analysis shows that: 1. Pregnancy changes RVR, renal flow and GFR dependent on NO-activation and sympathetic de-activation, but adjustments are different among species, strains and gestational ages; 2. These changes do not depend on adaptation of renal artery responsiveness; 3. It remains unknown at which cellular level pregnancy affects the pathways. Our meta-analysis suggests that renal changes during pregnancy in animals are qualitatively similar, even in comparison to humans, but quantitatively different.
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spelling pubmed-42278452014-11-18 Functional Vascular Changes of the Kidney during Pregnancy in Animals: A Systematic Review and Meta-Analysis van Drongelen, Joris de Vries, Rob Lotgering, Frederik K. Smits, Paul Spaanderman, Marc E. A. PLoS One Research Article Renal vascular responses to pregnancy have frequently been studied, by investigating renal vascular resistance (RVR), renal flow, glomerular filtration rate (GFR), and renal artery responses to stimuli. Nonetheless, several questions remain: 1. Which vasodilator pathways are activated and to what extent do they affect RVR, renal flow and GFR across species, strains and gestational ages, 2. Are these changes dependent on renal artery adaptation, 3. At which cellular level does pregnancy affect the involved pathways? In an attempt to answer the questions raised, we performed a systematic review and meta-analysis on animal data. We included 37 studies (116 responses). At mid-gestation, RVR and GFR change to a similar degree across species and strains, accompanied by variable change in renal flow. At least in rats, changes depend on NO activation. At late gestation, changes in RVR, renal flow and GFR vary between species and strains. In rats, these changes are effectuated by sympathetic stimulation. Overall, renal artery responsiveness to stimuli is unaffected by pregnancy, except for Sprague Dawley rats in which pregnancy enhances renal artery vascular compliance and reduces renal artery myogenic reactivity. Our meta-analysis shows that: 1. Pregnancy changes RVR, renal flow and GFR dependent on NO-activation and sympathetic de-activation, but adjustments are different among species, strains and gestational ages; 2. These changes do not depend on adaptation of renal artery responsiveness; 3. It remains unknown at which cellular level pregnancy affects the pathways. Our meta-analysis suggests that renal changes during pregnancy in animals are qualitatively similar, even in comparison to humans, but quantitatively different. Public Library of Science 2014-11-11 /pmc/articles/PMC4227845/ /pubmed/25386682 http://dx.doi.org/10.1371/journal.pone.0112084 Text en © 2014 van Drongelen et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
van Drongelen, Joris
de Vries, Rob
Lotgering, Frederik K.
Smits, Paul
Spaanderman, Marc E. A.
Functional Vascular Changes of the Kidney during Pregnancy in Animals: A Systematic Review and Meta-Analysis
title Functional Vascular Changes of the Kidney during Pregnancy in Animals: A Systematic Review and Meta-Analysis
title_full Functional Vascular Changes of the Kidney during Pregnancy in Animals: A Systematic Review and Meta-Analysis
title_fullStr Functional Vascular Changes of the Kidney during Pregnancy in Animals: A Systematic Review and Meta-Analysis
title_full_unstemmed Functional Vascular Changes of the Kidney during Pregnancy in Animals: A Systematic Review and Meta-Analysis
title_short Functional Vascular Changes of the Kidney during Pregnancy in Animals: A Systematic Review and Meta-Analysis
title_sort functional vascular changes of the kidney during pregnancy in animals: a systematic review and meta-analysis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4227845/
https://www.ncbi.nlm.nih.gov/pubmed/25386682
http://dx.doi.org/10.1371/journal.pone.0112084
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