Parkin depletion delays motor decline dose-dependently without overtly affecting neuropathology in α-synuclein transgenic mice

BACKGROUND: Mutations of the gene encoding the major component of Lewy bodies (LB), α-synuclein (α-syn), cause autosomal dominant forms of Parkinson’s disease (PD), whereas loss-of-function mutations of the gene encoding the multifunctional E3 ubiquitin-protein ligase Parkin account for autosomal re...

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Detalles Bibliográficos
Autores principales: Fournier, Margot, Roux, Amandine, Garrigue, Jérôme, Muriel, Marie-Paule, Blanche, Paul, Lashuel, Hilal A, Anderson, John P, Barbour, Robin, Huang, Jiping, du Montcel, Sophie Tezenas, Brice, Alexis, Corti, Olga
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4228309/
https://www.ncbi.nlm.nih.gov/pubmed/24192137
http://dx.doi.org/10.1186/1471-2202-14-135

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