The absence of myelin basic protein promotes neuroinflammation and reduces amyloid β-protein accumulation in Tg-5xFAD mice

BACKGROUND: Abnormal accumulation of amyloid β-protein (Aβ) in the brain plays an important role in the pathogenesis \of Alzheimer’s disease (AD). Aβ monomers assemble into oligomers and fibrils that promote neuronal dysfunction. This assembly pathway is influenced by naturally occurring brain molec...

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Detalles Bibliográficos
Autores principales: Ou-Yang, Ming-Hsuan, Van Nostrand, William E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4228351/
https://www.ncbi.nlm.nih.gov/pubmed/24188129
http://dx.doi.org/10.1186/1742-2094-10-134

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4228351/
https://www.ncbi.nlm.nih.gov/pubmed/24188129
http://dx.doi.org/10.1186/1742-2094-10-134

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