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Horizontal acquisition and a broad biodistribution typify simian foamy virus infection in a cohort of Macaca fascicularis

BACKGROUND: Foamy viruses are non-pathogenic in vivo and naturally infect all species of non-human primates (NHP). Simian foamy viruses (SFV) are highly prevalent in both free ranging and captive NHP but few longitudinal studies have been performed to assess the prevalence and biodistribution of SFV...

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Autores principales: Hood, Simon, Mitchell, Jane L, Sethi, Meera, Almond, Neil M, Cutler, Keith L, Rose, Nicola J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4228416/
https://www.ncbi.nlm.nih.gov/pubmed/24180225
http://dx.doi.org/10.1186/1743-422X-10-326
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author Hood, Simon
Mitchell, Jane L
Sethi, Meera
Almond, Neil M
Cutler, Keith L
Rose, Nicola J
author_facet Hood, Simon
Mitchell, Jane L
Sethi, Meera
Almond, Neil M
Cutler, Keith L
Rose, Nicola J
author_sort Hood, Simon
collection PubMed
description BACKGROUND: Foamy viruses are non-pathogenic in vivo and naturally infect all species of non-human primates (NHP). Simian foamy viruses (SFV) are highly prevalent in both free ranging and captive NHP but few longitudinal studies have been performed to assess the prevalence and biodistribution of SFV within captive NHP. METHOD: LTR and pol gene along with Gag antibody detection were undertaken to identify infection in a cohort of over 80 captive macaques. RESULTS: The prevalence of SFV was between 64% and 94% in different groups. Access to 23 dam-infant pairs allowed us to reveal horizontal transfer as the dominant route of SFV transmission in our cohort. Further, analysis of SFV from a range of tissues and blood revealed that macaques as young as six months old can be infected and that proviral biodistribution increases with age. CONCLUSIONS: These are the first data of this type for a captive cohort of cynomolgus macaques.
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spelling pubmed-42284162014-11-13 Horizontal acquisition and a broad biodistribution typify simian foamy virus infection in a cohort of Macaca fascicularis Hood, Simon Mitchell, Jane L Sethi, Meera Almond, Neil M Cutler, Keith L Rose, Nicola J Virol J Research BACKGROUND: Foamy viruses are non-pathogenic in vivo and naturally infect all species of non-human primates (NHP). Simian foamy viruses (SFV) are highly prevalent in both free ranging and captive NHP but few longitudinal studies have been performed to assess the prevalence and biodistribution of SFV within captive NHP. METHOD: LTR and pol gene along with Gag antibody detection were undertaken to identify infection in a cohort of over 80 captive macaques. RESULTS: The prevalence of SFV was between 64% and 94% in different groups. Access to 23 dam-infant pairs allowed us to reveal horizontal transfer as the dominant route of SFV transmission in our cohort. Further, analysis of SFV from a range of tissues and blood revealed that macaques as young as six months old can be infected and that proviral biodistribution increases with age. CONCLUSIONS: These are the first data of this type for a captive cohort of cynomolgus macaques. BioMed Central 2013-11-01 /pmc/articles/PMC4228416/ /pubmed/24180225 http://dx.doi.org/10.1186/1743-422X-10-326 Text en Copyright © 2013 Hood et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Hood, Simon
Mitchell, Jane L
Sethi, Meera
Almond, Neil M
Cutler, Keith L
Rose, Nicola J
Horizontal acquisition and a broad biodistribution typify simian foamy virus infection in a cohort of Macaca fascicularis
title Horizontal acquisition and a broad biodistribution typify simian foamy virus infection in a cohort of Macaca fascicularis
title_full Horizontal acquisition and a broad biodistribution typify simian foamy virus infection in a cohort of Macaca fascicularis
title_fullStr Horizontal acquisition and a broad biodistribution typify simian foamy virus infection in a cohort of Macaca fascicularis
title_full_unstemmed Horizontal acquisition and a broad biodistribution typify simian foamy virus infection in a cohort of Macaca fascicularis
title_short Horizontal acquisition and a broad biodistribution typify simian foamy virus infection in a cohort of Macaca fascicularis
title_sort horizontal acquisition and a broad biodistribution typify simian foamy virus infection in a cohort of macaca fascicularis
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4228416/
https://www.ncbi.nlm.nih.gov/pubmed/24180225
http://dx.doi.org/10.1186/1743-422X-10-326
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