Cargando…
The effect of rural-to-urban migration on renal function in an Indian population: cross-sectional data from the Hyderabad arm of the Indian Migration Study
BACKGROUND: Urban migration is associated with an increased risk of hypertension, obesity and diabetes in Indian migrants. This study assessed the relationship between internal migration and renal function in the Hyderabad arm of the Indian Migration Study. METHODS: We assessed 841 subjects; urban n...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2013
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4228419/ https://www.ncbi.nlm.nih.gov/pubmed/24176058 http://dx.doi.org/10.1186/1471-2369-14-240 |
_version_ | 1782343979538317312 |
---|---|
author | Bailey, Phillippa K Tomson, Charles RV Kinra, Sanjay Ebrahim, Shah Radhakrishna, KV Kuper, Hannah Nitsch, Dorothea Ben-Shlomo, Yoav |
author_facet | Bailey, Phillippa K Tomson, Charles RV Kinra, Sanjay Ebrahim, Shah Radhakrishna, KV Kuper, Hannah Nitsch, Dorothea Ben-Shlomo, Yoav |
author_sort | Bailey, Phillippa K |
collection | PubMed |
description | BACKGROUND: Urban migration is associated with an increased risk of hypertension, obesity and diabetes in Indian migrants. This study assessed the relationship between internal migration and renal function in the Hyderabad arm of the Indian Migration Study. METHODS: We assessed 841 subjects; urban non-migrants (n = 158), urban migrants (n = 424) and rural non-migrants (n = 259). Muscle mass was ascertained from DXA scanning. We derived urban life years for urban migrants and rural non-migrants. Multivariable linear regression was used to examine the association between tertiles of urban life years and 4-variable MDRD eGFR using Stata 11. RESULTS: Mean eGFR was lower in urban non-migrants and urban migrants compared to rural non-migrants. The prevalence of CKD 3-5 was higher in the rural non-migrant population (5.0%) than in the urban non-migrant populations (2.5%) due to a negatively skewed distribution of eGFR in rural non-migrants. As urban life years increased, eGFR declined (p = 0.008) though there was no obvious dose response effect. After adjustment for muscle mass, the association was attenuated and the trend was consistent with chance (p = 0.08). Further adjustment for vascular risk factors weakened the association to a small degree (p = 0.11). CONCLUSIONS: The high prevalence of reduced eGFR in rural areas requires further research. Urbanization was associated with reduced eGFR. This association appears mostly to be due to higher muscle mass with a small contribution from adverse vascular disease risk factors. |
format | Online Article Text |
id | pubmed-4228419 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-42284192014-11-13 The effect of rural-to-urban migration on renal function in an Indian population: cross-sectional data from the Hyderabad arm of the Indian Migration Study Bailey, Phillippa K Tomson, Charles RV Kinra, Sanjay Ebrahim, Shah Radhakrishna, KV Kuper, Hannah Nitsch, Dorothea Ben-Shlomo, Yoav BMC Nephrol Research Article BACKGROUND: Urban migration is associated with an increased risk of hypertension, obesity and diabetes in Indian migrants. This study assessed the relationship between internal migration and renal function in the Hyderabad arm of the Indian Migration Study. METHODS: We assessed 841 subjects; urban non-migrants (n = 158), urban migrants (n = 424) and rural non-migrants (n = 259). Muscle mass was ascertained from DXA scanning. We derived urban life years for urban migrants and rural non-migrants. Multivariable linear regression was used to examine the association between tertiles of urban life years and 4-variable MDRD eGFR using Stata 11. RESULTS: Mean eGFR was lower in urban non-migrants and urban migrants compared to rural non-migrants. The prevalence of CKD 3-5 was higher in the rural non-migrant population (5.0%) than in the urban non-migrant populations (2.5%) due to a negatively skewed distribution of eGFR in rural non-migrants. As urban life years increased, eGFR declined (p = 0.008) though there was no obvious dose response effect. After adjustment for muscle mass, the association was attenuated and the trend was consistent with chance (p = 0.08). Further adjustment for vascular risk factors weakened the association to a small degree (p = 0.11). CONCLUSIONS: The high prevalence of reduced eGFR in rural areas requires further research. Urbanization was associated with reduced eGFR. This association appears mostly to be due to higher muscle mass with a small contribution from adverse vascular disease risk factors. BioMed Central 2013-10-31 /pmc/articles/PMC4228419/ /pubmed/24176058 http://dx.doi.org/10.1186/1471-2369-14-240 Text en Copyright © 2013 Bailey et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Bailey, Phillippa K Tomson, Charles RV Kinra, Sanjay Ebrahim, Shah Radhakrishna, KV Kuper, Hannah Nitsch, Dorothea Ben-Shlomo, Yoav The effect of rural-to-urban migration on renal function in an Indian population: cross-sectional data from the Hyderabad arm of the Indian Migration Study |
title | The effect of rural-to-urban migration on renal function in an Indian population: cross-sectional data from the Hyderabad arm of the Indian Migration Study |
title_full | The effect of rural-to-urban migration on renal function in an Indian population: cross-sectional data from the Hyderabad arm of the Indian Migration Study |
title_fullStr | The effect of rural-to-urban migration on renal function in an Indian population: cross-sectional data from the Hyderabad arm of the Indian Migration Study |
title_full_unstemmed | The effect of rural-to-urban migration on renal function in an Indian population: cross-sectional data from the Hyderabad arm of the Indian Migration Study |
title_short | The effect of rural-to-urban migration on renal function in an Indian population: cross-sectional data from the Hyderabad arm of the Indian Migration Study |
title_sort | effect of rural-to-urban migration on renal function in an indian population: cross-sectional data from the hyderabad arm of the indian migration study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4228419/ https://www.ncbi.nlm.nih.gov/pubmed/24176058 http://dx.doi.org/10.1186/1471-2369-14-240 |
work_keys_str_mv | AT baileyphillippak theeffectofruraltourbanmigrationonrenalfunctioninanindianpopulationcrosssectionaldatafromthehyderabadarmoftheindianmigrationstudy AT tomsoncharlesrv theeffectofruraltourbanmigrationonrenalfunctioninanindianpopulationcrosssectionaldatafromthehyderabadarmoftheindianmigrationstudy AT kinrasanjay theeffectofruraltourbanmigrationonrenalfunctioninanindianpopulationcrosssectionaldatafromthehyderabadarmoftheindianmigrationstudy AT ebrahimshah theeffectofruraltourbanmigrationonrenalfunctioninanindianpopulationcrosssectionaldatafromthehyderabadarmoftheindianmigrationstudy AT radhakrishnakv theeffectofruraltourbanmigrationonrenalfunctioninanindianpopulationcrosssectionaldatafromthehyderabadarmoftheindianmigrationstudy AT kuperhannah theeffectofruraltourbanmigrationonrenalfunctioninanindianpopulationcrosssectionaldatafromthehyderabadarmoftheindianmigrationstudy AT nitschdorothea theeffectofruraltourbanmigrationonrenalfunctioninanindianpopulationcrosssectionaldatafromthehyderabadarmoftheindianmigrationstudy AT benshlomoyoav theeffectofruraltourbanmigrationonrenalfunctioninanindianpopulationcrosssectionaldatafromthehyderabadarmoftheindianmigrationstudy AT baileyphillippak effectofruraltourbanmigrationonrenalfunctioninanindianpopulationcrosssectionaldatafromthehyderabadarmoftheindianmigrationstudy AT tomsoncharlesrv effectofruraltourbanmigrationonrenalfunctioninanindianpopulationcrosssectionaldatafromthehyderabadarmoftheindianmigrationstudy AT kinrasanjay effectofruraltourbanmigrationonrenalfunctioninanindianpopulationcrosssectionaldatafromthehyderabadarmoftheindianmigrationstudy AT ebrahimshah effectofruraltourbanmigrationonrenalfunctioninanindianpopulationcrosssectionaldatafromthehyderabadarmoftheindianmigrationstudy AT radhakrishnakv effectofruraltourbanmigrationonrenalfunctioninanindianpopulationcrosssectionaldatafromthehyderabadarmoftheindianmigrationstudy AT kuperhannah effectofruraltourbanmigrationonrenalfunctioninanindianpopulationcrosssectionaldatafromthehyderabadarmoftheindianmigrationstudy AT nitschdorothea effectofruraltourbanmigrationonrenalfunctioninanindianpopulationcrosssectionaldatafromthehyderabadarmoftheindianmigrationstudy AT benshlomoyoav effectofruraltourbanmigrationonrenalfunctioninanindianpopulationcrosssectionaldatafromthehyderabadarmoftheindianmigrationstudy |