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Optimal Seasonal Timing of Oral Azithromycin for Malaria

Mass administration of azithromycin for trachoma has been shown to reduce malarial parasitemia. However, the optimal seasonal timing of such distributions for antimalarial benefit has not been established. We performed numerical analyses on a seasonally forced epidemic model (of Ross-Macdonald type)...

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Detalles Bibliográficos
Autores principales: Gao, Daozhou, Amza, Abdou, Nassirou, Baidou, Kadri, Boubacar, Sippl-Swezey, Nicholas, Liu, Fengchen, Ackley, Sarah F., Lietman, Thomas M., Porco, Travis C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society of Tropical Medicine and Hygiene 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4228890/
https://www.ncbi.nlm.nih.gov/pubmed/25223942
http://dx.doi.org/10.4269/ajtmh.13-0474
Descripción
Sumario:Mass administration of azithromycin for trachoma has been shown to reduce malarial parasitemia. However, the optimal seasonal timing of such distributions for antimalarial benefit has not been established. We performed numerical analyses on a seasonally forced epidemic model (of Ross-Macdonald type) with periodic impulsive annual mass treatment to address this question. We conclude that when azithromycin-based trachoma elimination programs occur in regions of seasonal malaria transmission, such as Niger, the optimal seasonal timing of mass drug administration (MDA) may not occur during the season of maximum transmission.