Unlocking a Caged Lysosomal Protein from a Polymeric Nanogel with a pH Trigger

[Image: see text] A polymeric nanogel has been used to sequester and turn off a lysosomal protein, acid α-glucosidase (GAA). The nanogel contains a β-thiopropionate cross-linker, which endows the nanogel with pH-sensitivity. While encapsulation of the enzyme fully turns off its activity, approximate...

Descripción completa

Detalles Bibliográficos
Autores principales: Molla, Mijanur Rahaman, Marcinko, Tyler, Prasad, Priyaa, Deming, Derrick, Garman, Scott C., Thayumanavan, S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4229022/
https://www.ncbi.nlm.nih.gov/pubmed/25291086
http://dx.doi.org/10.1021/bm501091p

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4229022/
https://www.ncbi.nlm.nih.gov/pubmed/25291086
http://dx.doi.org/10.1021/bm501091p

Ejemplares similares