Alzheimer's Therapeutics Targeting Amyloid Beta 1–42 Oligomers I: Abeta 42 Oligomer Binding to Specific Neuronal Receptors Is Displaced by Drug Candidates That Improve Cognitive Deficits

Synaptic dysfunction and loss caused by age-dependent accumulation of synaptotoxic beta amyloid (Abeta) 1–42 oligomers is proposed to underlie cognitive decline in Alzheimer's disease (AD). Alterations in membrane trafficking induced by Abeta oligomers mediates reduction in neuronal surface rec...

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Detalles Bibliográficos
Autores principales: Izzo, Nicholas J., Staniszewski, Agnes, To, Lillian, Fa, Mauro, Teich, Andrew F., Saeed, Faisal, Wostein, Harrison, Walko, Thomas, Vaswani, Anisha, Wardius, Meghan, Syed, Zanobia, Ravenscroft, Jessica, Mozzoni, Kelsie, Silky, Colleen, Rehak, Courtney, Yurko, Raymond, Finn, Patricia, Look, Gary, Rishton, Gilbert, Safferstein, Hank, Miller, Miles, Johanson, Conrad, Stopa, Edward, Windisch, Manfred, Hutter-Paier, Birgit, Shamloo, Mehrdad, Arancio, Ottavio, LeVine, Harry, Catalano, Susan M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4229098/
https://www.ncbi.nlm.nih.gov/pubmed/25390368
http://dx.doi.org/10.1371/journal.pone.0111898

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