A Two-Step Strategy to Enhance Activity of Low Potency Peptides

Novel strategies are needed to expedite the generation and optimization of peptide probes targeting G protein-coupled receptors (GPCRs). We have previously shown that membrane tethered ligands (MTLs), recombinant proteins comprised of a membrane anchor, an extracellular linker, and a peptide ligand...

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Detalles Bibliográficos
Autores principales: Doyle, Jamie R., Harwood, Benjamin N., Krishnaji, Subrahmanian Tarakkad, Krishnamurthy, Vijay M., Lin, Wei-En, Fortin, Jean-Philippe, Kumar, Krishna, Kopin, Alan S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4229100/
https://www.ncbi.nlm.nih.gov/pubmed/25391026
http://dx.doi.org/10.1371/journal.pone.0110502

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4229100/
https://www.ncbi.nlm.nih.gov/pubmed/25391026
http://dx.doi.org/10.1371/journal.pone.0110502

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