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A Recommended Numbering Scheme for Influenza A HA Subtypes
Comparisons of residues between sub-types of influenza virus is increasingly used to assess the zoonotic potential of a circulating strain and for comparative studies across subtypes. An analysis of N-terminal cleavage sites for thirteen subtypes of influenza A hemagglutinin (HA) sequences, has prev...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4229193/ https://www.ncbi.nlm.nih.gov/pubmed/25391151 http://dx.doi.org/10.1371/journal.pone.0112302 |
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author | Burke, David F. Smith, Derek J. |
author_facet | Burke, David F. Smith, Derek J. |
author_sort | Burke, David F. |
collection | PubMed |
description | Comparisons of residues between sub-types of influenza virus is increasingly used to assess the zoonotic potential of a circulating strain and for comparative studies across subtypes. An analysis of N-terminal cleavage sites for thirteen subtypes of influenza A hemagglutinin (HA) sequences, has previously been described by Nobusawa and colleagues. We have expanded this analysis for the eighteen known subtypes of influenza. Due to differences in the length of HA, we have included strains from multiple clades of H1 and H5, as well as strains of H5 and H7 subtypes with both high and low pathogenicity. Analysis of known structures of influenza A HA enables us to define amino acids which are structurally and functionally equivalent across all HA subtypes using a numbering system based on the mature HA sequence. We provide a list of equivalences for amino acids which are known to affect the phenotype of the virus. |
format | Online Article Text |
id | pubmed-4229193 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-42291932014-11-18 A Recommended Numbering Scheme for Influenza A HA Subtypes Burke, David F. Smith, Derek J. PLoS One Research Article Comparisons of residues between sub-types of influenza virus is increasingly used to assess the zoonotic potential of a circulating strain and for comparative studies across subtypes. An analysis of N-terminal cleavage sites for thirteen subtypes of influenza A hemagglutinin (HA) sequences, has previously been described by Nobusawa and colleagues. We have expanded this analysis for the eighteen known subtypes of influenza. Due to differences in the length of HA, we have included strains from multiple clades of H1 and H5, as well as strains of H5 and H7 subtypes with both high and low pathogenicity. Analysis of known structures of influenza A HA enables us to define amino acids which are structurally and functionally equivalent across all HA subtypes using a numbering system based on the mature HA sequence. We provide a list of equivalences for amino acids which are known to affect the phenotype of the virus. Public Library of Science 2014-11-12 /pmc/articles/PMC4229193/ /pubmed/25391151 http://dx.doi.org/10.1371/journal.pone.0112302 Text en © 2014 Burke, Smith http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Burke, David F. Smith, Derek J. A Recommended Numbering Scheme for Influenza A HA Subtypes |
title | A Recommended Numbering Scheme for Influenza A HA Subtypes |
title_full | A Recommended Numbering Scheme for Influenza A HA Subtypes |
title_fullStr | A Recommended Numbering Scheme for Influenza A HA Subtypes |
title_full_unstemmed | A Recommended Numbering Scheme for Influenza A HA Subtypes |
title_short | A Recommended Numbering Scheme for Influenza A HA Subtypes |
title_sort | recommended numbering scheme for influenza a ha subtypes |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4229193/ https://www.ncbi.nlm.nih.gov/pubmed/25391151 http://dx.doi.org/10.1371/journal.pone.0112302 |
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