The Actin Targeting Compound Chondramide Inhibits Breast Cancer Metastasis via Reduction of Cellular Contractility

BACKGROUND: A major player in the process of metastasis is the actin cytoskeleton as it forms key structures in both invasion mechanisms, mesenchymal and amoeboid migration. We tested the actin binding compound Chondramide as potential anti-metastatic agent. METHODS: In vivo, the effect of Chondrami...

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Detalles Bibliográficos
Autores principales: Menhofer, Magdalena H., Kubisch, Rebekka, Schreiner, Laura, Zorn, Matthias, Foerster, Florian, Mueller, Rolf, Raedler, Joachim O., Wagner, Ernst, Vollmar, Angelika M., Zahler, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4229209/
https://www.ncbi.nlm.nih.gov/pubmed/25391145
http://dx.doi.org/10.1371/journal.pone.0112542

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