Reprogramming Suppresses Premature Senescence Phenotypes of Werner Syndrome Cells and Maintains Chromosomal Stability over Long-Term Culture

Werner syndrome (WS) is a premature aging disorder characterized by chromosomal instability and cancer predisposition. Mutations in WRN are responsible for the disease and cause telomere dysfunction, resulting in accelerated aging. Recent studies have revealed that cells from WS patients can be succ...

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Detalles Bibliográficos
Autores principales: Shimamoto, Akira, Kagawa, Harunobu, Zensho, Kazumasa, Sera, Yukihiro, Kazuki, Yasuhiro, Osaki, Mitsuhiko, Oshimura, Mitsuo, Ishigaki, Yasuhito, Hamasaki, Kanya, Kodama, Yoshiaki, Yuasa, Shinsuke, Fukuda, Keiichi, Hirashima, Kyotaro, Seimiya, Hiroyuki, Koyama, Hirofumi, Shimizu, Takahiko, Takemoto, Minoru, Yokote, Koutaro, Goto, Makoto, Tahara, Hidetoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4229309/
https://www.ncbi.nlm.nih.gov/pubmed/25390333
http://dx.doi.org/10.1371/journal.pone.0112900

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