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Reprogramming Suppresses Premature Senescence Phenotypes of Werner Syndrome Cells and Maintains Chromosomal Stability over Long-Term Culture
Werner syndrome (WS) is a premature aging disorder characterized by chromosomal instability and cancer predisposition. Mutations in WRN are responsible for the disease and cause telomere dysfunction, resulting in accelerated aging. Recent studies have revealed that cells from WS patients can be succ...
Autores principales: | Shimamoto, Akira, Kagawa, Harunobu, Zensho, Kazumasa, Sera, Yukihiro, Kazuki, Yasuhiro, Osaki, Mitsuhiko, Oshimura, Mitsuo, Ishigaki, Yasuhito, Hamasaki, Kanya, Kodama, Yoshiaki, Yuasa, Shinsuke, Fukuda, Keiichi, Hirashima, Kyotaro, Seimiya, Hiroyuki, Koyama, Hirofumi, Shimizu, Takahiko, Takemoto, Minoru, Yokote, Koutaro, Goto, Makoto, Tahara, Hidetoshi |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4229309/ https://www.ncbi.nlm.nih.gov/pubmed/25390333 http://dx.doi.org/10.1371/journal.pone.0112900 |
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