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Late term tolerance in head neck cancer patients irradiated in the IMRT era
BACKGROUND: The aim was to quantify severe transient and persisting late term effects in our single institution head neck cancer (HNC) cohort treated with curatively intended intensity modulated radiation therapy (IMRT). Hypothesis was if a 2-year follow up (FU) is sufficient to estimate the long te...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4229314/ https://www.ncbi.nlm.nih.gov/pubmed/24192223 http://dx.doi.org/10.1186/1748-717X-8-259 |
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author | Studer, Gabriela Linsenmeier, Claudia Riesterer, Oliver Najafi, Yousef Brown, Michelle Yousefi, Bita Bredell, Marius Huber, Gerhard Schmid, Stephan Studer, Stephan Zwahlen, Roger Rordorf, Tamara Glanzmann, Christoph |
author_facet | Studer, Gabriela Linsenmeier, Claudia Riesterer, Oliver Najafi, Yousef Brown, Michelle Yousefi, Bita Bredell, Marius Huber, Gerhard Schmid, Stephan Studer, Stephan Zwahlen, Roger Rordorf, Tamara Glanzmann, Christoph |
author_sort | Studer, Gabriela |
collection | PubMed |
description | BACKGROUND: The aim was to quantify severe transient and persisting late term effects in our single institution head neck cancer (HNC) cohort treated with curatively intended intensity modulated radiation therapy (IMRT). Hypothesis was if a 2-year follow up (FU) is sufficient to estimate the long term tolerance in HNC irradiated in the IMRT era. METHODS: Between 01/2002-8/2012, 707/1211 (58%) consecutively treated IMRT patients met the inclusion criteria of a FU time >12 months and loco-regional disease control (LRC). 45% presented with loco-regionally advanced disease; 55% were referred for curative definitive IMRT (66 Gy-72 Gy in 30–35 fractions), 45% underwent postoperative IMRT (60-66 Gy in 30–33 fractions). Systemic concomitant therapy was administered in 85%. Highly consistent treatment procedures were performed with respect to contouring processes, dose constraints, radiation schedules, and the use of systemic therapy. Grade 3/4 late term effects were prospectively assessed and analyzed with respect to subgroups at particular risk for specific late effects. RESULTS: Mean/median FU of the cohort was 41/35 months (15–124). 13% of the patients (92/707) experienced any grade 3/4 late effects (101 events in 92/707 patients), 81% in the first 12 months after radiation. 4% of all developed persisting late grade 3/4 effects (25 events in 25/707 patients). CONCLUSIONS: IMRT led to a high late term tolerance in loco-regionally disease free HNC patients. The onset of any G3/4 effects showed a plateau at 2 years. The question of the cervical vessel tolerance in disease free long time survivors is still open and currently under evaluation at our institution. |
format | Online Article Text |
id | pubmed-4229314 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-42293142014-11-13 Late term tolerance in head neck cancer patients irradiated in the IMRT era Studer, Gabriela Linsenmeier, Claudia Riesterer, Oliver Najafi, Yousef Brown, Michelle Yousefi, Bita Bredell, Marius Huber, Gerhard Schmid, Stephan Studer, Stephan Zwahlen, Roger Rordorf, Tamara Glanzmann, Christoph Radiat Oncol Research BACKGROUND: The aim was to quantify severe transient and persisting late term effects in our single institution head neck cancer (HNC) cohort treated with curatively intended intensity modulated radiation therapy (IMRT). Hypothesis was if a 2-year follow up (FU) is sufficient to estimate the long term tolerance in HNC irradiated in the IMRT era. METHODS: Between 01/2002-8/2012, 707/1211 (58%) consecutively treated IMRT patients met the inclusion criteria of a FU time >12 months and loco-regional disease control (LRC). 45% presented with loco-regionally advanced disease; 55% were referred for curative definitive IMRT (66 Gy-72 Gy in 30–35 fractions), 45% underwent postoperative IMRT (60-66 Gy in 30–33 fractions). Systemic concomitant therapy was administered in 85%. Highly consistent treatment procedures were performed with respect to contouring processes, dose constraints, radiation schedules, and the use of systemic therapy. Grade 3/4 late term effects were prospectively assessed and analyzed with respect to subgroups at particular risk for specific late effects. RESULTS: Mean/median FU of the cohort was 41/35 months (15–124). 13% of the patients (92/707) experienced any grade 3/4 late effects (101 events in 92/707 patients), 81% in the first 12 months after radiation. 4% of all developed persisting late grade 3/4 effects (25 events in 25/707 patients). CONCLUSIONS: IMRT led to a high late term tolerance in loco-regionally disease free HNC patients. The onset of any G3/4 effects showed a plateau at 2 years. The question of the cervical vessel tolerance in disease free long time survivors is still open and currently under evaluation at our institution. BioMed Central 2013-11-05 /pmc/articles/PMC4229314/ /pubmed/24192223 http://dx.doi.org/10.1186/1748-717X-8-259 Text en Copyright © 2013 Studer et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Studer, Gabriela Linsenmeier, Claudia Riesterer, Oliver Najafi, Yousef Brown, Michelle Yousefi, Bita Bredell, Marius Huber, Gerhard Schmid, Stephan Studer, Stephan Zwahlen, Roger Rordorf, Tamara Glanzmann, Christoph Late term tolerance in head neck cancer patients irradiated in the IMRT era |
title | Late term tolerance in head neck cancer patients irradiated in the IMRT era |
title_full | Late term tolerance in head neck cancer patients irradiated in the IMRT era |
title_fullStr | Late term tolerance in head neck cancer patients irradiated in the IMRT era |
title_full_unstemmed | Late term tolerance in head neck cancer patients irradiated in the IMRT era |
title_short | Late term tolerance in head neck cancer patients irradiated in the IMRT era |
title_sort | late term tolerance in head neck cancer patients irradiated in the imrt era |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4229314/ https://www.ncbi.nlm.nih.gov/pubmed/24192223 http://dx.doi.org/10.1186/1748-717X-8-259 |
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