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Linking diet, physical activity, cardiorespiratory fitness and obesity to serum metabolite networks: findings from a population-based study
OBJECTIVE: It is not yet resolved how lifestyle factors and intermediate phenotypes interrelate with metabolic pathways. We aimed to investigate the associations between diet, physical activity, cardiorespiratory fitness and obesity with serum metabolite networks in a population-based study. METHODS...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4229626/ https://www.ncbi.nlm.nih.gov/pubmed/24608922 http://dx.doi.org/10.1038/ijo.2014.39 |
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author | Floegel, A Wientzek, A Bachlechner, U Jacobs, S Drogan, D Prehn, C Adamski, J Krumsiek, J Schulze, M B Pischon, T Boeing, H |
author_facet | Floegel, A Wientzek, A Bachlechner, U Jacobs, S Drogan, D Prehn, C Adamski, J Krumsiek, J Schulze, M B Pischon, T Boeing, H |
author_sort | Floegel, A |
collection | PubMed |
description | OBJECTIVE: It is not yet resolved how lifestyle factors and intermediate phenotypes interrelate with metabolic pathways. We aimed to investigate the associations between diet, physical activity, cardiorespiratory fitness and obesity with serum metabolite networks in a population-based study. METHODS: The present study included 2380 participants of a randomly drawn subcohort of the European Prospective Investigation into Cancer and Nutrition-Potsdam. Targeted metabolomics was used to measure 127 serum metabolites. Additional data were available including anthropometric measurements, dietary assessment including intake of whole-grain bread, coffee and cake and cookies by food frequency questionnaire, and objectively measured physical activity energy expenditure and cardiorespiratory fitness in a subsample of 100 participants. In a data-driven approach, Gaussian graphical modeling was used to draw metabolite networks and depict relevant associations between exposures and serum metabolites. In addition, the relationship of different exposure metabolite networks was estimated. RESULTS: In the serum metabolite network, the different metabolite classes could be separated. There was a big group of phospholipids and acylcarnitines, a group of amino acids and C6-sugar. Amino acids were particularly positively associated with cardiorespiratory fitness and physical activity. C6-sugar and acylcarnitines were positively associated with obesity and inversely with intake of whole-grain bread. Phospholipids showed opposite associations with obesity and coffee intake. Metabolite networks of coffee intake and obesity were strongly inversely correlated (body mass index (BMI): r=−0.57 and waist circumference: r=−0.59). A strong positive correlation was observed between metabolite networks of BMI and waist circumference (r=0.99), as well as the metabolite networks of cake and cookie intake with cardiorespiratory fitness and intake of whole-grain bread (r=0.52 and r=0.50; respectively). CONCLUSIONS: Lifestyle factors and phenotypes seem to interrelate in various metabolic pathways. A possible protective effect of coffee could be mediated via counterbalance of pathways of obesity involving hepatic phospholipids. Experimental studies should validate the biological mechanisms. |
format | Online Article Text |
id | pubmed-4229626 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-42296262014-11-17 Linking diet, physical activity, cardiorespiratory fitness and obesity to serum metabolite networks: findings from a population-based study Floegel, A Wientzek, A Bachlechner, U Jacobs, S Drogan, D Prehn, C Adamski, J Krumsiek, J Schulze, M B Pischon, T Boeing, H Int J Obes (Lond) Original Article OBJECTIVE: It is not yet resolved how lifestyle factors and intermediate phenotypes interrelate with metabolic pathways. We aimed to investigate the associations between diet, physical activity, cardiorespiratory fitness and obesity with serum metabolite networks in a population-based study. METHODS: The present study included 2380 participants of a randomly drawn subcohort of the European Prospective Investigation into Cancer and Nutrition-Potsdam. Targeted metabolomics was used to measure 127 serum metabolites. Additional data were available including anthropometric measurements, dietary assessment including intake of whole-grain bread, coffee and cake and cookies by food frequency questionnaire, and objectively measured physical activity energy expenditure and cardiorespiratory fitness in a subsample of 100 participants. In a data-driven approach, Gaussian graphical modeling was used to draw metabolite networks and depict relevant associations between exposures and serum metabolites. In addition, the relationship of different exposure metabolite networks was estimated. RESULTS: In the serum metabolite network, the different metabolite classes could be separated. There was a big group of phospholipids and acylcarnitines, a group of amino acids and C6-sugar. Amino acids were particularly positively associated with cardiorespiratory fitness and physical activity. C6-sugar and acylcarnitines were positively associated with obesity and inversely with intake of whole-grain bread. Phospholipids showed opposite associations with obesity and coffee intake. Metabolite networks of coffee intake and obesity were strongly inversely correlated (body mass index (BMI): r=−0.57 and waist circumference: r=−0.59). A strong positive correlation was observed between metabolite networks of BMI and waist circumference (r=0.99), as well as the metabolite networks of cake and cookie intake with cardiorespiratory fitness and intake of whole-grain bread (r=0.52 and r=0.50; respectively). CONCLUSIONS: Lifestyle factors and phenotypes seem to interrelate in various metabolic pathways. A possible protective effect of coffee could be mediated via counterbalance of pathways of obesity involving hepatic phospholipids. Experimental studies should validate the biological mechanisms. Nature Publishing Group 2014-11 2014-04-01 /pmc/articles/PMC4229626/ /pubmed/24608922 http://dx.doi.org/10.1038/ijo.2014.39 Text en Copyright © 2014 Macmillan Publishers Limited http://creativecommons.org/licenses/by-nc-sa/3.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/ |
spellingShingle | Original Article Floegel, A Wientzek, A Bachlechner, U Jacobs, S Drogan, D Prehn, C Adamski, J Krumsiek, J Schulze, M B Pischon, T Boeing, H Linking diet, physical activity, cardiorespiratory fitness and obesity to serum metabolite networks: findings from a population-based study |
title | Linking diet, physical activity, cardiorespiratory fitness and obesity to serum metabolite networks: findings from a population-based study |
title_full | Linking diet, physical activity, cardiorespiratory fitness and obesity to serum metabolite networks: findings from a population-based study |
title_fullStr | Linking diet, physical activity, cardiorespiratory fitness and obesity to serum metabolite networks: findings from a population-based study |
title_full_unstemmed | Linking diet, physical activity, cardiorespiratory fitness and obesity to serum metabolite networks: findings from a population-based study |
title_short | Linking diet, physical activity, cardiorespiratory fitness and obesity to serum metabolite networks: findings from a population-based study |
title_sort | linking diet, physical activity, cardiorespiratory fitness and obesity to serum metabolite networks: findings from a population-based study |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4229626/ https://www.ncbi.nlm.nih.gov/pubmed/24608922 http://dx.doi.org/10.1038/ijo.2014.39 |
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