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Mechanisms of planar cell polarity establishment in Drosophila

Correct patterning and polarization of epithelial and mesenchymal cells are essential for morphogenesis and function of all organs and organisms. Epithelial cells are generally polarized in two axes: (a) the ubiquitous apical-basal axis and (b) polarity within the plane of the epithelium. The latter...

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Autores principales: Carvajal-Gonzalez, Jose Maria, Mlodzik, Marek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Faculty of 1000 Ltd 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4229721/
https://www.ncbi.nlm.nih.gov/pubmed/25580252
http://dx.doi.org/10.12703/P6-98
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author Carvajal-Gonzalez, Jose Maria
Mlodzik, Marek
author_facet Carvajal-Gonzalez, Jose Maria
Mlodzik, Marek
author_sort Carvajal-Gonzalez, Jose Maria
collection PubMed
description Correct patterning and polarization of epithelial and mesenchymal cells are essential for morphogenesis and function of all organs and organisms. Epithelial cells are generally polarized in two axes: (a) the ubiquitous apical-basal axis and (b) polarity within the plane of the epithelium. The latter is generally referred to as planar cell polarity (PCP) and also is found in several contexts of mesenchymal cell patterning. In Drosophila, all adult structures display PCP features, and two conserved molecular systems (the Fat [Ft]/Dachsous [Ds] system and the Frizzled [Fz]/PCP pathway) that regulate this process have been identified. Although significant progress has been made in dissecting aspects of PCP signaling within cells, much remains to be discovered about the mechanisms of long-range and local PCP cell-cell interactions. Here, we discuss the current models based on Drosophila studies and incorporate recent insights into this long-standing cell and developmental biology problem.
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spelling pubmed-42297212015-01-09 Mechanisms of planar cell polarity establishment in Drosophila Carvajal-Gonzalez, Jose Maria Mlodzik, Marek F1000Prime Rep Review Article Correct patterning and polarization of epithelial and mesenchymal cells are essential for morphogenesis and function of all organs and organisms. Epithelial cells are generally polarized in two axes: (a) the ubiquitous apical-basal axis and (b) polarity within the plane of the epithelium. The latter is generally referred to as planar cell polarity (PCP) and also is found in several contexts of mesenchymal cell patterning. In Drosophila, all adult structures display PCP features, and two conserved molecular systems (the Fat [Ft]/Dachsous [Ds] system and the Frizzled [Fz]/PCP pathway) that regulate this process have been identified. Although significant progress has been made in dissecting aspects of PCP signaling within cells, much remains to be discovered about the mechanisms of long-range and local PCP cell-cell interactions. Here, we discuss the current models based on Drosophila studies and incorporate recent insights into this long-standing cell and developmental biology problem. Faculty of 1000 Ltd 2014-11-04 /pmc/articles/PMC4229721/ /pubmed/25580252 http://dx.doi.org/10.12703/P6-98 Text en © 2014 Faculty of 1000 Ltd http://creativecommons.org/licenses/by-nc/3.0/legalcode All F1000Prime Reports articles are distributed under the terms of the Creative Commons Attribution-Non Commercial License, which permits non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Carvajal-Gonzalez, Jose Maria
Mlodzik, Marek
Mechanisms of planar cell polarity establishment in Drosophila
title Mechanisms of planar cell polarity establishment in Drosophila
title_full Mechanisms of planar cell polarity establishment in Drosophila
title_fullStr Mechanisms of planar cell polarity establishment in Drosophila
title_full_unstemmed Mechanisms of planar cell polarity establishment in Drosophila
title_short Mechanisms of planar cell polarity establishment in Drosophila
title_sort mechanisms of planar cell polarity establishment in drosophila
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4229721/
https://www.ncbi.nlm.nih.gov/pubmed/25580252
http://dx.doi.org/10.12703/P6-98
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