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Mechanisms of planar cell polarity establishment in Drosophila
Correct patterning and polarization of epithelial and mesenchymal cells are essential for morphogenesis and function of all organs and organisms. Epithelial cells are generally polarized in two axes: (a) the ubiquitous apical-basal axis and (b) polarity within the plane of the epithelium. The latter...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Faculty of 1000 Ltd
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4229721/ https://www.ncbi.nlm.nih.gov/pubmed/25580252 http://dx.doi.org/10.12703/P6-98 |
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author | Carvajal-Gonzalez, Jose Maria Mlodzik, Marek |
author_facet | Carvajal-Gonzalez, Jose Maria Mlodzik, Marek |
author_sort | Carvajal-Gonzalez, Jose Maria |
collection | PubMed |
description | Correct patterning and polarization of epithelial and mesenchymal cells are essential for morphogenesis and function of all organs and organisms. Epithelial cells are generally polarized in two axes: (a) the ubiquitous apical-basal axis and (b) polarity within the plane of the epithelium. The latter is generally referred to as planar cell polarity (PCP) and also is found in several contexts of mesenchymal cell patterning. In Drosophila, all adult structures display PCP features, and two conserved molecular systems (the Fat [Ft]/Dachsous [Ds] system and the Frizzled [Fz]/PCP pathway) that regulate this process have been identified. Although significant progress has been made in dissecting aspects of PCP signaling within cells, much remains to be discovered about the mechanisms of long-range and local PCP cell-cell interactions. Here, we discuss the current models based on Drosophila studies and incorporate recent insights into this long-standing cell and developmental biology problem. |
format | Online Article Text |
id | pubmed-4229721 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Faculty of 1000 Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-42297212015-01-09 Mechanisms of planar cell polarity establishment in Drosophila Carvajal-Gonzalez, Jose Maria Mlodzik, Marek F1000Prime Rep Review Article Correct patterning and polarization of epithelial and mesenchymal cells are essential for morphogenesis and function of all organs and organisms. Epithelial cells are generally polarized in two axes: (a) the ubiquitous apical-basal axis and (b) polarity within the plane of the epithelium. The latter is generally referred to as planar cell polarity (PCP) and also is found in several contexts of mesenchymal cell patterning. In Drosophila, all adult structures display PCP features, and two conserved molecular systems (the Fat [Ft]/Dachsous [Ds] system and the Frizzled [Fz]/PCP pathway) that regulate this process have been identified. Although significant progress has been made in dissecting aspects of PCP signaling within cells, much remains to be discovered about the mechanisms of long-range and local PCP cell-cell interactions. Here, we discuss the current models based on Drosophila studies and incorporate recent insights into this long-standing cell and developmental biology problem. Faculty of 1000 Ltd 2014-11-04 /pmc/articles/PMC4229721/ /pubmed/25580252 http://dx.doi.org/10.12703/P6-98 Text en © 2014 Faculty of 1000 Ltd http://creativecommons.org/licenses/by-nc/3.0/legalcode All F1000Prime Reports articles are distributed under the terms of the Creative Commons Attribution-Non Commercial License, which permits non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Carvajal-Gonzalez, Jose Maria Mlodzik, Marek Mechanisms of planar cell polarity establishment in Drosophila |
title | Mechanisms of planar cell polarity establishment in Drosophila |
title_full | Mechanisms of planar cell polarity establishment in Drosophila |
title_fullStr | Mechanisms of planar cell polarity establishment in Drosophila |
title_full_unstemmed | Mechanisms of planar cell polarity establishment in Drosophila |
title_short | Mechanisms of planar cell polarity establishment in Drosophila |
title_sort | mechanisms of planar cell polarity establishment in drosophila |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4229721/ https://www.ncbi.nlm.nih.gov/pubmed/25580252 http://dx.doi.org/10.12703/P6-98 |
work_keys_str_mv | AT carvajalgonzalezjosemaria mechanismsofplanarcellpolarityestablishmentindrosophila AT mlodzikmarek mechanismsofplanarcellpolarityestablishmentindrosophila |