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Research priorities for the development and implementation of serological tools for malaria surveillance
Surveillance is a key component of control and elimination programs. Malaria surveillance has been typically reliant on case reporting by health services, entomological estimates and parasitemia (Plasmodium species) point prevalence. However, these techniques become less sensitive and relatively cos...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Faculty of 1000 Ltd
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4229730/ https://www.ncbi.nlm.nih.gov/pubmed/25580254 http://dx.doi.org/10.12703/P6-100 |
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author | Elliott, Salenna R. Fowkes, Freya J.I. Richards, Jack S. Reiling, Linda Drew, Damien R. Beeson, James G. |
author_facet | Elliott, Salenna R. Fowkes, Freya J.I. Richards, Jack S. Reiling, Linda Drew, Damien R. Beeson, James G. |
author_sort | Elliott, Salenna R. |
collection | PubMed |
description | Surveillance is a key component of control and elimination programs. Malaria surveillance has been typically reliant on case reporting by health services, entomological estimates and parasitemia (Plasmodium species) point prevalence. However, these techniques become less sensitive and relatively costly as transmission declines. There is great potential for the development and application of serological biomarkers of malaria exposure as sero-surveillance tools to strengthen malaria control and elimination. Antibodies to malaria antigens are sensitive biomarkers of population-level malaria exposure and can be used to identify hotspots of malaria transmission, estimate transmission levels, monitor changes over time or the impact of interventions on transmission, confirm malaria elimination, and monitor re-emergence of malaria. Sero-surveillance tools could be used in reference laboratories or developed as simple point-of-care tests for community-based surveillance, and different applications and target populations dictate the technical performance required from assays that are determined by properties of antigens and antibody responses. To advance the development of sero-surveillance tools for malaria elimination, major gaps in our knowledge need to be addressed through further research. These include greater knowledge of potential antigens, the sensitivity and specificity of antibody responses, and the longevity of these responses and defining antigens and antibodies that differentiate between exposure to Plasmodium falciparum and P. vivax. Additionally, a better understanding of the influence of host factors, such as age, genetics, and comorbidities on antibody responses in different populations is needed. |
format | Online Article Text |
id | pubmed-4229730 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Faculty of 1000 Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-42297302015-01-09 Research priorities for the development and implementation of serological tools for malaria surveillance Elliott, Salenna R. Fowkes, Freya J.I. Richards, Jack S. Reiling, Linda Drew, Damien R. Beeson, James G. F1000Prime Rep Review Article Surveillance is a key component of control and elimination programs. Malaria surveillance has been typically reliant on case reporting by health services, entomological estimates and parasitemia (Plasmodium species) point prevalence. However, these techniques become less sensitive and relatively costly as transmission declines. There is great potential for the development and application of serological biomarkers of malaria exposure as sero-surveillance tools to strengthen malaria control and elimination. Antibodies to malaria antigens are sensitive biomarkers of population-level malaria exposure and can be used to identify hotspots of malaria transmission, estimate transmission levels, monitor changes over time or the impact of interventions on transmission, confirm malaria elimination, and monitor re-emergence of malaria. Sero-surveillance tools could be used in reference laboratories or developed as simple point-of-care tests for community-based surveillance, and different applications and target populations dictate the technical performance required from assays that are determined by properties of antigens and antibody responses. To advance the development of sero-surveillance tools for malaria elimination, major gaps in our knowledge need to be addressed through further research. These include greater knowledge of potential antigens, the sensitivity and specificity of antibody responses, and the longevity of these responses and defining antigens and antibodies that differentiate between exposure to Plasmodium falciparum and P. vivax. Additionally, a better understanding of the influence of host factors, such as age, genetics, and comorbidities on antibody responses in different populations is needed. Faculty of 1000 Ltd 2014-11-04 /pmc/articles/PMC4229730/ /pubmed/25580254 http://dx.doi.org/10.12703/P6-100 Text en © 2014 Faculty of 1000 Ltd http://creativecommons.org/licenses/by-nc/3.0/legalcode All F1000Prime Reports articles are distributed under the terms of the Creative Commons Attribution-Non Commercial License, which permits non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Elliott, Salenna R. Fowkes, Freya J.I. Richards, Jack S. Reiling, Linda Drew, Damien R. Beeson, James G. Research priorities for the development and implementation of serological tools for malaria surveillance |
title | Research priorities for the development and implementation of serological tools for malaria surveillance |
title_full | Research priorities for the development and implementation of serological tools for malaria surveillance |
title_fullStr | Research priorities for the development and implementation of serological tools for malaria surveillance |
title_full_unstemmed | Research priorities for the development and implementation of serological tools for malaria surveillance |
title_short | Research priorities for the development and implementation of serological tools for malaria surveillance |
title_sort | research priorities for the development and implementation of serological tools for malaria surveillance |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4229730/ https://www.ncbi.nlm.nih.gov/pubmed/25580254 http://dx.doi.org/10.12703/P6-100 |
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