CNS-targeted glucocorticoid reduces pathology in mouse model of amyotrophic lateral sclerosis

BACKGROUND: Hallmarks of CNS inflammation, including microglial and astrocyte activation, are prominent features in post-mortem tissue from amyotrophic lateral sclerosis (ALS) patients and in mice overexpressing mutant superoxide dismutase-1 (SOD1(G93A)). Administration of non-targeted glucocorticoi...

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Detalles Bibliográficos
Autores principales: Evans, Matthew C, Gaillard, Pieter J, de Boer, Marco, Appeldoorn, Chantal, Dorland, Rick, Sibson, Nicola R, Turner, Martin R, Anthony, Daniel C, Stolp, Helen B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4229735/
https://www.ncbi.nlm.nih.gov/pubmed/24923195
http://dx.doi.org/10.1186/2051-5960-2-66

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