Obesity and diabetes cause cognitive dysfunction in the absence of accelerated β-amyloid deposition in a novel murine model of mixed or vascular dementia

Mid-life obesity and type 2 diabetes mellitus (T2DM) confer a modest, increased risk for Alzheimer’s disease (AD), though the underlying mechanisms are unknown. We have created a novel mouse model that recapitulates features of T2DM and AD by crossing morbidly obese and diabetic db/db mice with APP(...

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Detalles Bibliográficos
Autores principales: Niedowicz, Dana M, Reeves, Valerie L, Platt, Thomas L, Kohler, Katharina, Beckett, Tina L, Powell, David K, Lee, Tiffany L, Sexton, Travis R, Song, Eun Suk, Brewer, Lawrence D, Latimer, Caitlin S, Kraner, Susan D, Larson, Kara L, Ozcan, Sabire, Norris, Christopher M, Hersh, Louis B, Porter, Nada M, Wilcock, Donna M, Murphy, Michael Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4229778/
https://www.ncbi.nlm.nih.gov/pubmed/24916066
http://dx.doi.org/10.1186/2051-5960-2-64

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