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Increased 5-hydroxymethylcytosine and decreased 5-methylcytosine are indicators of global epigenetic dysregulation in diffuse intrinsic pontine glioma

INTRODUCTION: Diffuse intrinsic pontine glioma (DIPG) is a malignant pediatric brain tumor associated with dismal outcome. Recent high-throughput molecular studies have shown a high frequency of mutations in histone-encoding genes (H3F3A and HIST1B) and distinctive epigenetic alterations in these tu...

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Detalles Bibliográficos
Autores principales:	Ahsan, Sama, Raabe, Eric H, Haffner, Michael C, Vaghasia, Ajay, Warren, Katherine E, Quezado, Martha, Ballester, Leomar Y, Nazarian, Javad, Eberhart, Charles G, Rodriguez, Fausto J
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4229804/ https://www.ncbi.nlm.nih.gov/pubmed/24894482 http://dx.doi.org/10.1186/2051-5960-2-59

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