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Platelets, a reliable source for peripheral Alzheimer’s disease biomarkers?
Peripheral biomarkers play an indispensable role in quick and reliable diagnoses of any kind of disease. With the population ageing, the number of people suffering from age-related diseases is expected to rise dramatically over the coming decades. In particular, all types of cognitive deficits, such...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4229876/ https://www.ncbi.nlm.nih.gov/pubmed/24934666 http://dx.doi.org/10.1186/2051-5960-2-65 |
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author | Veitinger, Michael Varga, Balazs Guterres, Sheila B Zellner, Maria |
author_facet | Veitinger, Michael Varga, Balazs Guterres, Sheila B Zellner, Maria |
author_sort | Veitinger, Michael |
collection | PubMed |
description | Peripheral biomarkers play an indispensable role in quick and reliable diagnoses of any kind of disease. With the population ageing, the number of people suffering from age-related diseases is expected to rise dramatically over the coming decades. In particular, all types of cognitive deficits, such as Alzheimer’s disease, will increase. Alzheimer’s disease is characterised mainly by coexistence of amyloid plaques and neurofibrillary tangles in brain. Reliable identification of such molecular characteristics antemortem, however, is problematic due to restricted availability of appropriate sample material and definitive diagnosis is only possible postmortem. Currently, the best molecular biomarkers available for antemortem diagnosis originate from cerebrospinal fluid. Though, this is not convenient for routine diagnosis because of the required invasive lumbar puncture. As a consequence, there is a growing demand for additional peripheral biomarkers in a more readily accessible sample material. Blood platelets, due to shared biochemical properties with neurons, can constitute an attractive alternative as discussed here. This review summarises potential platelet Alzheimer’s disease biomarkers, their role, implication, and alteration in the disease. For easy comparison of their performance, the Hedge effect size was calculated whenever data were available. |
format | Online Article Text |
id | pubmed-4229876 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-42298762014-11-14 Platelets, a reliable source for peripheral Alzheimer’s disease biomarkers? Veitinger, Michael Varga, Balazs Guterres, Sheila B Zellner, Maria Acta Neuropathol Commun Review Peripheral biomarkers play an indispensable role in quick and reliable diagnoses of any kind of disease. With the population ageing, the number of people suffering from age-related diseases is expected to rise dramatically over the coming decades. In particular, all types of cognitive deficits, such as Alzheimer’s disease, will increase. Alzheimer’s disease is characterised mainly by coexistence of amyloid plaques and neurofibrillary tangles in brain. Reliable identification of such molecular characteristics antemortem, however, is problematic due to restricted availability of appropriate sample material and definitive diagnosis is only possible postmortem. Currently, the best molecular biomarkers available for antemortem diagnosis originate from cerebrospinal fluid. Though, this is not convenient for routine diagnosis because of the required invasive lumbar puncture. As a consequence, there is a growing demand for additional peripheral biomarkers in a more readily accessible sample material. Blood platelets, due to shared biochemical properties with neurons, can constitute an attractive alternative as discussed here. This review summarises potential platelet Alzheimer’s disease biomarkers, their role, implication, and alteration in the disease. For easy comparison of their performance, the Hedge effect size was calculated whenever data were available. BioMed Central 2014-06-16 /pmc/articles/PMC4229876/ /pubmed/24934666 http://dx.doi.org/10.1186/2051-5960-2-65 Text en © Veitinger et al.; licensee BioMed Central Ltd. 2014 This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Review Veitinger, Michael Varga, Balazs Guterres, Sheila B Zellner, Maria Platelets, a reliable source for peripheral Alzheimer’s disease biomarkers? |
title | Platelets, a reliable source for peripheral Alzheimer’s disease biomarkers? |
title_full | Platelets, a reliable source for peripheral Alzheimer’s disease biomarkers? |
title_fullStr | Platelets, a reliable source for peripheral Alzheimer’s disease biomarkers? |
title_full_unstemmed | Platelets, a reliable source for peripheral Alzheimer’s disease biomarkers? |
title_short | Platelets, a reliable source for peripheral Alzheimer’s disease biomarkers? |
title_sort | platelets, a reliable source for peripheral alzheimer’s disease biomarkers? |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4229876/ https://www.ncbi.nlm.nih.gov/pubmed/24934666 http://dx.doi.org/10.1186/2051-5960-2-65 |
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