Drug repurposing screen identifies lestaurtinib amplifies the ability of the poly (ADP-ribose) polymerase 1 inhibitor AG14361 to kill breast cancer associated gene-1 mutant and wild type breast cancer cells

INTRODUCTION: Breast cancer is a devastating disease that results in approximately 40,000 deaths each year in the USA. Current drug screening and chemopreventatitive methods are suboptimal, due in part to the poor specificity of compounds for cancer cells. Poly (ADP-ribose) polymerase 1 (PARP1) inhi...

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Detalles Bibliográficos
Autores principales: Vazquez-Ortiz, Guelaguetza, Chisholm, Cristine, Xu, Xiaoling, Lahusen, Tyler J, Li, Cuiling, Sakamuru, Srilatha, Huang, Ruili, Thomas, Craig J, Xia, Menghang, Deng, Chuxia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4229979/
https://www.ncbi.nlm.nih.gov/pubmed/24962108
http://dx.doi.org/10.1186/bcr3682

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