Cargando…

Persistent inflammation and T cell exhaustion in severe sepsis in the elderly

INTRODUCTION: Sepsis is known as a complex immunological response with hyperinflammation in the acute phase followed by immunosuppression. Although aging is crucial in sepsis, the impact of aging on inflammation and immunosuppression is still unclear. The purpose of this study was to investigate the...

Descripción completa

Detalles Bibliográficos
Autores principales:	Inoue, Shigeaki, Suzuki, Kodai, Komori, Yukako, Morishita, Yukiko, Suzuki-Utsunomiya, Kyoko, Hozumi, Katsuto, Inokuchi, Sadaki, Sato, Takehito
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4230031/ https://www.ncbi.nlm.nih.gov/pubmed/24962182 http://dx.doi.org/10.1186/cc13941

Ejemplares similares

Sepsis induces incomplete M2 phenotype polarization in peritoneal exudate cells in mice
por: Watanabe, Nobuo, et al.
Publicado: (2016)

Comparative Effectiveness of Emergency Resuscitative Thoracotomy versus Closed Chest Compressions among Patients with Critical Blunt Trauma: A Nationwide Cohort Study in Japan
por: Suzuki, Kodai, et al.
Publicado: (2016)

Impaired innate and adaptive immunity of accelerated-aged Klotho mice in sepsis
por: Inoue, S, et al.
Publicado: (2012)

Decreased peripheral CD4(+)/CD8(+ )lymphocytes and poor prognosis in aged sepsis
por: Inoue, S, et al.
Publicado: (2012)

Detection of pathogenic bacteria in the blood from sepsis patients using 16S rRNA gene amplicon sequencing analysis
por: Watanabe, Nobuo, et al.
Publicado: (2018)

A cell-based high-throughput screening assay system for inhibitor compounds of antigen presentation by HLA class II molecule
por: Watanabe, Nobuo, et al.
Publicado: (2017)

The prehospital quick SOFA score is associated with in-hospital mortality in noninfected patients: A retrospective, cross-sectional study
por: Kitahara, Osamu, et al.
Publicado: (2018)

Podoplanin is indispensable for cell motility and platelet-induced epithelial-to-mesenchymal transition-related gene expression in esophagus squamous carcinoma TE11A cells
por: Watanabe, Nobuo, et al.
Publicado: (2020)

Characteristic of the acute drug intoxication conveyed by Kanagawa helicopter emergency medical service
por: Sugita, Mariko, et al.
Publicado: (2017)

Tu1553: SPECIFIC IMMUNOGLOBLIN A INDUCED BY THE PERSISTENT COLONIZATION OF ADHERENT-INVASIVE E.COLI LIMITS PATHOBINT LOCALIZATION TO THE EPITHELIAL NICHE
por: Imai, Jin, et al.
Publicado: (2022)

A pull-down and slot blot-based screening system for inhibitor compounds of the podoplanin-CLEC-2 interaction
por: Watanabe, Nobuo, et al.
Publicado: (2019)

Delta-like 1 and Delta-like 4 differently require their extracellular domains for triggering Notch signaling in mice
por: Hirano, Ken-ichi, et al.
Publicado: (2020)

Dll1 maintains quiescence of adult neural stem cells and segregates asymmetrically during mitosis
por: Kawaguchi, Daichi, et al.
Publicado: (2013)

Gas6 ameliorates intestinal mucosal immunosenescence to prevent the translocation of a gut pathobiont, Klebsiella pneumoniae, to the liver
por: Tsugawa, Hitoshi, et al.
Publicado: (2023)

Pronuclear injection-based mouse targeted transgenesis for reproducible and highly efficient transgene expression
por: Ohtsuka, Masato, et al.
Publicado: (2010)

Jagged1-induced Notch activation contributes to the acquisition of bortezomib resistance in myeloma cells
por: Muguruma, Yukari, et al.
Publicado: (2017)

High-fat diet in early life triggers both reversible and persistent epigenetic changes in the medaka fish (Oryzias latipes)
por: Inoue, Yusuke, et al.
Publicado: (2023)

Do not attempt resuscitation order in Japan
por: Nakagawa, Yoshihide, et al.
Publicado: (2017)

Cardiac arrest caused by diphenhydramine overdose
por: Nishino, Tomoya, et al.
Publicado: (2018)

Dll1 Can Function as a Ligand of Notch1 and Notch2 in the Thymic Epithelium
por: Hirano, Ken-ichi, et al.
Publicado: (2022)

Importance of the capability for complete resuscitative treatment combining surgery and interventional radiology for potentially lethal multiple injuries: A case report
por: Otsuka, Hiroyuki, et al.
Publicado: (2017)

Impact of emergency physicians competent in severe trauma management, surgical techniques, and interventional radiology on trauma management
por: Otsuka, Hiroyuki, et al.
Publicado: (2018)

Effect of resuscitative endovascular balloon occlusion of the aorta in hemodynamically unstable patients with multiple severe torso trauma: a retrospective study
por: Otsuka, Hiroyuki, et al.
Publicado: (2018)

A rapidly progressing lymphocyte exhaustion after severe sepsis
por: Monneret, Guillaume, et al.
Publicado: (2012)

Relationship between Child Care Exhaustion and Breastfeeding Type at Two and Six Months in a Cohort of 1210 Japanese Mothers
por: Suzuki, Tomoya, et al.
Publicado: (2022)

Serum levels of presepsin reffects the APACHE II and SOFA scores in patients with sepsis
por: Sato, R, et al.
Publicado: (2013)

Tertiary lymphoid organs in the inflammatory myopathy associated with PD-1 inhibitors
por: Matsubara, Shiro, et al.
Publicado: (2019)

CD83 expression characterizes precursor exhausted T cell population
por: Wu, Zhiwen, et al.
Publicado: (2023)

Lethal hemothorax following thoracic dislocated spinal fracture: the usefulness of arterial embolization
por: Morita, Seiji, et al.
Publicado: (2009)

Current strategy for hollow viscus injury with active bleeding: A case report
por: Otsuka, Hiroyuki, et al.
Publicado: (2019)

Serum potassium level as a biomarker for acute caffeine poisoning
por: Tsuji, Tomoatsu, et al.
Publicado: (2020)

Integrated analysis of multi-omics data reveals T cell exhaustion in sepsis
por: Li, Qiaoke, et al.
Publicado: (2023)

SUPPLEMENTATION WITH NICOTINAMIDE RIBOSIDE ATTENUATES T CELL EXHAUSTION AND IMPROVES SURVIVAL IN SEPSIS
por: Zhao, Guang-ju, et al.
Publicado: (2023)

Macrophage depletion by clodronate liposome attenuates muscle injury and inflammation following exhaustive exercise
por: Kawanishi, Noriaki, et al.
Publicado: (2015)

The association of elevated reactive oxygen species levels from neutrophils with low-grade inflammation in the elderly
por: Ogawa, Kishiko, et al.
Publicado: (2008)

Neutrophil Depletion Attenuates Acute Liver Stress after Exhaustive Exercise in Mice
por: MIZOKAMI, TSUBASA, et al.
Publicado: (2023)

Immunity, inflammation and sepsis: new insights and persistent questions
por: Frazier, W Joshua
Publicado: (2011)

Arterial embolization of an extrapleural hematoma from a dislocated fracture of the lumbar spine: a case report
por: Morita, Seiji, et al.
Publicado: (2009)

Expression of podoplanin and vimentin is correlated with prognosis in esophageal squamous cell carcinoma
por: TANAKA, MAKIKO, et al.
Publicado: (2015)

Impact of a streamlined trauma management approach and determinants of mortality among hemodynamically unstable patients with severe multiple injuries: a before-and-after retrospective cohort study
por: Otsuka, Hiroyuki, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_n42kr69re02ra1229tddc6a8nt