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COX-2 overexpression in resected pancreatic head adenocarcinomas correlates with favourable prognosis

BACKGROUND: Overexpression of cyclooxygenase-2 (COX-2) has been implicated in oncogenesis and progression of adenocarcinomas of the pancreatic head. The data on the prognostic importance of COX expression in these tumours is inconsistent and conflicting. We evaluated how COX-2 overexpression affecte...

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Autores principales: Pomianowska, Ewa, Schjølberg, Aasa R, Clausen, Ole Petter F, Gladhaug, Ivar P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4230243/
https://www.ncbi.nlm.nih.gov/pubmed/24950702
http://dx.doi.org/10.1186/1471-2407-14-458
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author Pomianowska, Ewa
Schjølberg, Aasa R
Clausen, Ole Petter F
Gladhaug, Ivar P
author_facet Pomianowska, Ewa
Schjølberg, Aasa R
Clausen, Ole Petter F
Gladhaug, Ivar P
author_sort Pomianowska, Ewa
collection PubMed
description BACKGROUND: Overexpression of cyclooxygenase-2 (COX-2) has been implicated in oncogenesis and progression of adenocarcinomas of the pancreatic head. The data on the prognostic importance of COX expression in these tumours is inconsistent and conflicting. We evaluated how COX-2 overexpression affected overall postoperative survival in pancreatic head adenocarcinomas. METHODS: The study included 230 consecutive pancreatoduodenectomies for pancreatic cancer (PC, n = 92), ampullary cancer (AC, n = 62) and distal bile duct cancer (DBC, n = 76). COX-2 expression was assessed by immunohistochemistry. Associations between COX-2 expression and histopathologic variables including degree of differentiation, histopathologic type of differentiation (pancreatobiliary vs. intestinal) and lymph node ratio (LNR) were evaluated. Unadjusted and adjusted survival analysis was performed. RESULTS: COX-2 staining was positive in 71% of PC, 77% in AC and 72% in DBC. Irrespective of tumour origin, overall patient survival was more favourable in patients with COX-2 positive tumours than COX-2 negative (p = 0.043 in PC, p = 0.011 in AC, p = 0.06 in DBC). In tumours of pancreatobiliary type of histopathological differentiation, COX-2 expression did not significantly affect overall patient survival. In AC with intestinal differentiation COX-2 expression significantly predicted favourable survival (p = 0.003). In PC, COX-2 expression was significantly associated with high degree of differentiation (p = 0.002). COX-2 and LNR independently predicted good prognosis in a multivariate model. CONCLUSIONS: COX-2 is overexpressed in pancreatic cancer, ampullary cancer and distal bile duct cancer and confers a survival benefit in all three cancer types. In pancreatic cancer, COX-2 overexpression is significantly associated with the degree of differentiation and independently predicts a favourable prognosis.
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spelling pubmed-42302432014-11-14 COX-2 overexpression in resected pancreatic head adenocarcinomas correlates with favourable prognosis Pomianowska, Ewa Schjølberg, Aasa R Clausen, Ole Petter F Gladhaug, Ivar P BMC Cancer Research Article BACKGROUND: Overexpression of cyclooxygenase-2 (COX-2) has been implicated in oncogenesis and progression of adenocarcinomas of the pancreatic head. The data on the prognostic importance of COX expression in these tumours is inconsistent and conflicting. We evaluated how COX-2 overexpression affected overall postoperative survival in pancreatic head adenocarcinomas. METHODS: The study included 230 consecutive pancreatoduodenectomies for pancreatic cancer (PC, n = 92), ampullary cancer (AC, n = 62) and distal bile duct cancer (DBC, n = 76). COX-2 expression was assessed by immunohistochemistry. Associations between COX-2 expression and histopathologic variables including degree of differentiation, histopathologic type of differentiation (pancreatobiliary vs. intestinal) and lymph node ratio (LNR) were evaluated. Unadjusted and adjusted survival analysis was performed. RESULTS: COX-2 staining was positive in 71% of PC, 77% in AC and 72% in DBC. Irrespective of tumour origin, overall patient survival was more favourable in patients with COX-2 positive tumours than COX-2 negative (p = 0.043 in PC, p = 0.011 in AC, p = 0.06 in DBC). In tumours of pancreatobiliary type of histopathological differentiation, COX-2 expression did not significantly affect overall patient survival. In AC with intestinal differentiation COX-2 expression significantly predicted favourable survival (p = 0.003). In PC, COX-2 expression was significantly associated with high degree of differentiation (p = 0.002). COX-2 and LNR independently predicted good prognosis in a multivariate model. CONCLUSIONS: COX-2 is overexpressed in pancreatic cancer, ampullary cancer and distal bile duct cancer and confers a survival benefit in all three cancer types. In pancreatic cancer, COX-2 overexpression is significantly associated with the degree of differentiation and independently predicts a favourable prognosis. BioMed Central 2014-06-20 /pmc/articles/PMC4230243/ /pubmed/24950702 http://dx.doi.org/10.1186/1471-2407-14-458 Text en Copyright © 2014 Pomianowska et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Pomianowska, Ewa
Schjølberg, Aasa R
Clausen, Ole Petter F
Gladhaug, Ivar P
COX-2 overexpression in resected pancreatic head adenocarcinomas correlates with favourable prognosis
title COX-2 overexpression in resected pancreatic head adenocarcinomas correlates with favourable prognosis
title_full COX-2 overexpression in resected pancreatic head adenocarcinomas correlates with favourable prognosis
title_fullStr COX-2 overexpression in resected pancreatic head adenocarcinomas correlates with favourable prognosis
title_full_unstemmed COX-2 overexpression in resected pancreatic head adenocarcinomas correlates with favourable prognosis
title_short COX-2 overexpression in resected pancreatic head adenocarcinomas correlates with favourable prognosis
title_sort cox-2 overexpression in resected pancreatic head adenocarcinomas correlates with favourable prognosis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4230243/
https://www.ncbi.nlm.nih.gov/pubmed/24950702
http://dx.doi.org/10.1186/1471-2407-14-458
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