BlmB and TlmB Provide Resistance to the Bleomycin Family of Antitumor Antibiotics by N-Acetylating Metal-Free Bleomycin, Tallysomycin, Phleomycin, and Zorbamycin

[Image: see text] The bleomycin (BLM) family of glycopeptide-derived antitumor antibiotics consists of BLMs, tallysomycins (TLMs), phleomycins (PLMs), and zorbamycin (ZBM). The self-resistant elements BlmB and TlmB, discovered from the BLM- and TLM-producing organisms Streptomyces verticillus ATCC15...

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Detalles Bibliográficos
Autores principales: Coughlin, Jane M., Rudolf, Jeffrey D., Wendt-Pienkowski, Evelyn, Wang, Liyan, Unsin, Claudia, Galm, Ute, Yang, Dong, Tao, Meifeng, Shen, Ben
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4230324/
https://www.ncbi.nlm.nih.gov/pubmed/25299801
http://dx.doi.org/10.1021/bi501121e

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