Bioengineering of a human whole tooth: progress and challenge

A major challenge in stem cell-based bioengineering of an implantable human tooth is to identify appropriate sources of postnatal stem cells that are odontogenic competent as the epithelial component due to the lack of enamel epithelial cells in adult teeth. In a recent issue (2013, 2:6) of Cell Reg...

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Detalles Bibliográficos
Autores principales: Zhang, Yanding, Chen, YiPing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4230350/
https://www.ncbi.nlm.nih.gov/pubmed/25408887
http://dx.doi.org/10.1186/2045-9769-3-8
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author Zhang, Yanding
Chen, YiPing
author_facet Zhang, Yanding
Chen, YiPing
author_sort Zhang, Yanding
collection PubMed
description A major challenge in stem cell-based bioengineering of an implantable human tooth is to identify appropriate sources of postnatal stem cells that are odontogenic competent as the epithelial component due to the lack of enamel epithelial cells in adult teeth. In a recent issue (2013, 2:6) of Cell Regeneration, Cai and colleagues reported that epithelial sheets derived from human induced pluripotent stem cells (iPSCs) can functionally substitute for tooth germ epithelium to regenerate tooth-like structures, providing an appealing stem cell source for future human tooth regeneration.
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spelling pubmed-42303502014-11-18 Bioengineering of a human whole tooth: progress and challenge Zhang, Yanding Chen, YiPing Cell Regen Commentary A major challenge in stem cell-based bioengineering of an implantable human tooth is to identify appropriate sources of postnatal stem cells that are odontogenic competent as the epithelial component due to the lack of enamel epithelial cells in adult teeth. In a recent issue (2013, 2:6) of Cell Regeneration, Cai and colleagues reported that epithelial sheets derived from human induced pluripotent stem cells (iPSCs) can functionally substitute for tooth germ epithelium to regenerate tooth-like structures, providing an appealing stem cell source for future human tooth regeneration. BioMed Central 2014-04-30 /pmc/articles/PMC4230350/ /pubmed/25408887 http://dx.doi.org/10.1186/2045-9769-3-8 Text en © Zhang and Chen; licensee BioMed Central Ltd. 2014 This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.
spellingShingle Commentary
Zhang, Yanding
Chen, YiPing
Bioengineering of a human whole tooth: progress and challenge
title Bioengineering of a human whole tooth: progress and challenge
title_full Bioengineering of a human whole tooth: progress and challenge
title_fullStr Bioengineering of a human whole tooth: progress and challenge
title_full_unstemmed Bioengineering of a human whole tooth: progress and challenge
title_short Bioengineering of a human whole tooth: progress and challenge
title_sort bioengineering of a human whole tooth: progress and challenge
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4230350/
https://www.ncbi.nlm.nih.gov/pubmed/25408887
http://dx.doi.org/10.1186/2045-9769-3-8
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