Elective orthopedic and cardiopulmonary bypass surgery causes a reduction in serum endostatin levels

BACKGROUND: Endostatin is an endogenous inhibitor of angiogenesis that inhibits neovascularisation. The aim of the study was to evaluate the effect of elective surgery on endostatin levels. METHODS: Blood samples were collected prior to elective surgery and 4 and 30 days postoperatively in 2 patient...

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Detalles Bibliográficos
Autores principales: Åkerfeldt, Torbjörn, Gunningberg, Lena, Swenne, Christine Leo, Ronquist, Göran, Larsson, Anders
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4230358/
https://www.ncbi.nlm.nih.gov/pubmed/25380724
http://dx.doi.org/10.1186/s40001-014-0061-9
Descripción
Sumario:BACKGROUND: Endostatin is an endogenous inhibitor of angiogenesis that inhibits neovascularisation. The aim of the study was to evaluate the effect of elective surgery on endostatin levels. METHODS: Blood samples were collected prior to elective surgery and 4 and 30 days postoperatively in 2 patient groups: orthopedic surgery (n =27) and coronary bypass patients (n =21). Serum endostatin levels were measured by ELISA. RESULTS: Serum endostatin was significantly reduced 30 days after surgery in comparison with presurgical values in both the orthopedic (P =0.03) and cardiopulmonary surgery (P =0.04) group. CONCLUSION: Serum endostatin is reduced 30 days after surgery. This reduction would favor angiogenesis and wound-healing.

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