Elective orthopedic and cardiopulmonary bypass surgery causes a reduction in serum endostatin levels

BACKGROUND: Endostatin is an endogenous inhibitor of angiogenesis that inhibits neovascularisation. The aim of the study was to evaluate the effect of elective surgery on endostatin levels. METHODS: Blood samples were collected prior to elective surgery and 4 and 30 days postoperatively in 2 patient...

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Autores principales: Åkerfeldt, Torbjörn, Gunningberg, Lena, Swenne, Christine Leo, Ronquist, Göran, Larsson, Anders
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4230358/
https://www.ncbi.nlm.nih.gov/pubmed/25380724
http://dx.doi.org/10.1186/s40001-014-0061-9
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author Åkerfeldt, Torbjörn
Gunningberg, Lena
Swenne, Christine Leo
Ronquist, Göran
Larsson, Anders
author_facet Åkerfeldt, Torbjörn
Gunningberg, Lena
Swenne, Christine Leo
Ronquist, Göran
Larsson, Anders
author_sort Åkerfeldt, Torbjörn
collection PubMed
description BACKGROUND: Endostatin is an endogenous inhibitor of angiogenesis that inhibits neovascularisation. The aim of the study was to evaluate the effect of elective surgery on endostatin levels. METHODS: Blood samples were collected prior to elective surgery and 4 and 30 days postoperatively in 2 patient groups: orthopedic surgery (n =27) and coronary bypass patients (n =21). Serum endostatin levels were measured by ELISA. RESULTS: Serum endostatin was significantly reduced 30 days after surgery in comparison with presurgical values in both the orthopedic (P =0.03) and cardiopulmonary surgery (P =0.04) group. CONCLUSION: Serum endostatin is reduced 30 days after surgery. This reduction would favor angiogenesis and wound-healing.
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spelling pubmed-42303582014-11-14 Elective orthopedic and cardiopulmonary bypass surgery causes a reduction in serum endostatin levels Åkerfeldt, Torbjörn Gunningberg, Lena Swenne, Christine Leo Ronquist, Göran Larsson, Anders Eur J Med Res Research Article BACKGROUND: Endostatin is an endogenous inhibitor of angiogenesis that inhibits neovascularisation. The aim of the study was to evaluate the effect of elective surgery on endostatin levels. METHODS: Blood samples were collected prior to elective surgery and 4 and 30 days postoperatively in 2 patient groups: orthopedic surgery (n =27) and coronary bypass patients (n =21). Serum endostatin levels were measured by ELISA. RESULTS: Serum endostatin was significantly reduced 30 days after surgery in comparison with presurgical values in both the orthopedic (P =0.03) and cardiopulmonary surgery (P =0.04) group. CONCLUSION: Serum endostatin is reduced 30 days after surgery. This reduction would favor angiogenesis and wound-healing. BioMed Central 2014-11-08 /pmc/articles/PMC4230358/ /pubmed/25380724 http://dx.doi.org/10.1186/s40001-014-0061-9 Text en © Åkerfeldt et al.; licensee BioMed Central Ltd. 2014 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Åkerfeldt, Torbjörn
Gunningberg, Lena
Swenne, Christine Leo
Ronquist, Göran
Larsson, Anders
Elective orthopedic and cardiopulmonary bypass surgery causes a reduction in serum endostatin levels
title Elective orthopedic and cardiopulmonary bypass surgery causes a reduction in serum endostatin levels
title_full Elective orthopedic and cardiopulmonary bypass surgery causes a reduction in serum endostatin levels
title_fullStr Elective orthopedic and cardiopulmonary bypass surgery causes a reduction in serum endostatin levels
title_full_unstemmed Elective orthopedic and cardiopulmonary bypass surgery causes a reduction in serum endostatin levels
title_short Elective orthopedic and cardiopulmonary bypass surgery causes a reduction in serum endostatin levels
title_sort elective orthopedic and cardiopulmonary bypass surgery causes a reduction in serum endostatin levels
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4230358/
https://www.ncbi.nlm.nih.gov/pubmed/25380724
http://dx.doi.org/10.1186/s40001-014-0061-9
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