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Rapid Computational Prediction of Thermostabilizing Mutations for G Protein-Coupled Receptors
[Image: see text] G protein-coupled receptors (GPCRs) are highly dynamic and often denature when extracted in detergents. Deriving thermostable mutants has been a successful strategy to stabilize GPCRs in detergents, but this process is experimentally tedious. We have developed a computational metho...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American
Chemical Society
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4230369/ https://www.ncbi.nlm.nih.gov/pubmed/25400524 http://dx.doi.org/10.1021/ct500616v |