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The association of maternal prenatal psychosocial stress with vascular function in the child at age 10–11 years: findings from the Avon longitudinal study of parents and children

OBJECTIVE: To investigate whether (1) maternal psychosocial stress (depression/anxiety) during pregnancy is associated with offspring vascular function and (2) whether any association differs depending on the gestational timing of exposure to stress. We also investigated whether any association is l...

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Autores principales: van Dijk, Aimée E, Dawe, Karen, Deanfield, John, Stronks, Karien, Gemke, Reinoud JBJ, Vrijkotte, Tanja GM, Lawlor, Debbie A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4230381/
https://www.ncbi.nlm.nih.gov/pubmed/23559536
http://dx.doi.org/10.1177/2047487313486039
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author van Dijk, Aimée E
Dawe, Karen
Deanfield, John
Stronks, Karien
Gemke, Reinoud JBJ
Vrijkotte, Tanja GM
Lawlor, Debbie A
author_facet van Dijk, Aimée E
Dawe, Karen
Deanfield, John
Stronks, Karien
Gemke, Reinoud JBJ
Vrijkotte, Tanja GM
Lawlor, Debbie A
author_sort van Dijk, Aimée E
collection PubMed
description OBJECTIVE: To investigate whether (1) maternal psychosocial stress (depression/anxiety) during pregnancy is associated with offspring vascular function and (2) whether any association differs depending on the gestational timing of exposure to stress. We also investigated whether any association is likely to be due to intrauterine mechanisms by (3) comparing with the association of paternal stress with offspring vascular function and (4) examining whether any prenatal association is explained by maternal postnatal stress. METHODS AND RESULTS: Associations were examined in a UK birth cohort, with offspring outcomes (systolic and diastolic blood pressure, SBP and DBP, endothelial function assessed by brachial artery flow-mediated dilatation (FMD); arterial stiffness assessed by carotid to radial pulse wave velocity (PWV), brachial artery distensibility (DC), and brachial artery diameter (BD) assessed at age 10–11 years (n = 4318). Maternal depressive symptoms and anxiety were assessed at 18 and 32 weeks gestation and 8 months postnatally. Paternal symptoms were assessed at week 19. With the exception of DBP and BD, there were no associations of maternal depressive symptoms with any of the vascular outcomes. Maternal depressive and anxiety symptoms were associated with lower offspring DBP and wider BD, though the latter attenuated to the null with adjustment for confounding factors. Paternal symptoms were not associated with offspring outcomes. Maternal postnatal depressive symptoms were associated with lower offspring SBP. CONCLUSIONS: We found no evidence to support the hypothesis that maternal stress during pregnancy adversely affects offspring vascular function at age 10–12 years via intrauterine mechanisms.
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spelling pubmed-42303812014-11-19 The association of maternal prenatal psychosocial stress with vascular function in the child at age 10–11 years: findings from the Avon longitudinal study of parents and children van Dijk, Aimée E Dawe, Karen Deanfield, John Stronks, Karien Gemke, Reinoud JBJ Vrijkotte, Tanja GM Lawlor, Debbie A Eur J Prev Cardiol Cardiovascular Disease OBJECTIVE: To investigate whether (1) maternal psychosocial stress (depression/anxiety) during pregnancy is associated with offspring vascular function and (2) whether any association differs depending on the gestational timing of exposure to stress. We also investigated whether any association is likely to be due to intrauterine mechanisms by (3) comparing with the association of paternal stress with offspring vascular function and (4) examining whether any prenatal association is explained by maternal postnatal stress. METHODS AND RESULTS: Associations were examined in a UK birth cohort, with offspring outcomes (systolic and diastolic blood pressure, SBP and DBP, endothelial function assessed by brachial artery flow-mediated dilatation (FMD); arterial stiffness assessed by carotid to radial pulse wave velocity (PWV), brachial artery distensibility (DC), and brachial artery diameter (BD) assessed at age 10–11 years (n = 4318). Maternal depressive symptoms and anxiety were assessed at 18 and 32 weeks gestation and 8 months postnatally. Paternal symptoms were assessed at week 19. With the exception of DBP and BD, there were no associations of maternal depressive symptoms with any of the vascular outcomes. Maternal depressive and anxiety symptoms were associated with lower offspring DBP and wider BD, though the latter attenuated to the null with adjustment for confounding factors. Paternal symptoms were not associated with offspring outcomes. Maternal postnatal depressive symptoms were associated with lower offspring SBP. CONCLUSIONS: We found no evidence to support the hypothesis that maternal stress during pregnancy adversely affects offspring vascular function at age 10–12 years via intrauterine mechanisms. SAGE Publications 2013-04-04 2014-09 /pmc/articles/PMC4230381/ /pubmed/23559536 http://dx.doi.org/10.1177/2047487313486039 Text en © The European Society of Cardiology 2013 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav http://creativecommons.org/licenses/by/3.0/ This article is distributed under the terms of the Creative Commons Attribution 3.0 License (http://www.creativecommons.org/licenses/by/3.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (http://www.uk.sagepub.com/aboutus/openaccess.htm).
spellingShingle Cardiovascular Disease
van Dijk, Aimée E
Dawe, Karen
Deanfield, John
Stronks, Karien
Gemke, Reinoud JBJ
Vrijkotte, Tanja GM
Lawlor, Debbie A
The association of maternal prenatal psychosocial stress with vascular function in the child at age 10–11 years: findings from the Avon longitudinal study of parents and children
title The association of maternal prenatal psychosocial stress with vascular function in the child at age 10–11 years: findings from the Avon longitudinal study of parents and children
title_full The association of maternal prenatal psychosocial stress with vascular function in the child at age 10–11 years: findings from the Avon longitudinal study of parents and children
title_fullStr The association of maternal prenatal psychosocial stress with vascular function in the child at age 10–11 years: findings from the Avon longitudinal study of parents and children
title_full_unstemmed The association of maternal prenatal psychosocial stress with vascular function in the child at age 10–11 years: findings from the Avon longitudinal study of parents and children
title_short The association of maternal prenatal psychosocial stress with vascular function in the child at age 10–11 years: findings from the Avon longitudinal study of parents and children
title_sort association of maternal prenatal psychosocial stress with vascular function in the child at age 10–11 years: findings from the avon longitudinal study of parents and children
topic Cardiovascular Disease
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4230381/
https://www.ncbi.nlm.nih.gov/pubmed/23559536
http://dx.doi.org/10.1177/2047487313486039
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